TRAIL:TRAIL Receptor Trimer:FADD complex binds procaspase-8

Stable Identifier
R-HSA-75146
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

FADD recruits caspase-8 precursor to trimeric complex of TRAIL (TNFSF10) and TRAIL receptors (TNFRSF10A or TNFRSF10B) (Sprick et al. 2000).

Literature References
PubMed ID Title Journal Year
10894160 FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

Sprick, MR, Weigand, MA, Rieser, E, Rauch, CT, Juo, P, Blenis, J, Krammer, PH, Walczak, H

Immunity 2000
Participants
Participant Of
hasEvent
Orthologous Events
Authored
Reviewed