FasL/ CD95L signaling

Stable Identifier
R-HSA-75157
Type
Pathway
Species
Homo sapiens
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The Fas family of cell surface receptors initiate the apototic pathway through interaction with the external ligand, FasL. The cytoplasmic domain of Fas interacts with a number of molecules in the transduction of the external signal to the cytoplasmic side of the cell membrane. The most notable cytoplasmic domain is the Death Domain (DD) that is involved in recruiting the FAS-associating death domain-containing protein (FADD). This interaction drives downstream events.

Literature References
PubMed ID Title Journal Year
11048727 The biochemistry of apoptosis.

Hengartner, MO

Nature 2000
Participants
Participant Of
Event Information
Orthologous Events
Authored
Reviewed
Created