Reactome | RAD50 [nucleoplasm]

RAD50 [nucleoplasm]

Stable Identifier

R-HSA-75160

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser for interactor UniProt:Q14676 MDC1

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External Reference Information

External Reference

UniProt:Q92878 RAD50

Gene Names

RAD50

Chain

chain:1-1312

Reference Genes

BioGPS Gene:10111 RAD50

COSMIC (genes):RAD50 RAD50

CTD Gene:10111 RAD50

dbSNP Gene:10111 RAD50

ENSEMBL:ENSG00000113522 RAD50

HGNC:9816 RAD50

KEGG Gene (Homo sapiens):10111 RAD50

Monarch:10111 RAD50

NCBI Gene:10111 RAD50

OMIM:604040 RAD50

UCSC:Q92878 RAD50

Reference Transcript

RefSeq:NM_005732.3 RAD50

Other Identifiers

0002510161

0005270600

10111

11730280_a_at

11730281_a_at

11730282_a_at

1533_at

16989054

208393_s_at

209349_at

238656_at

2828606

2828607

2828608

2828609

2828610

2828612

2828613

2828614

2828615

2828617

2828618

2828619

2828620

2828621

2828622

2828623

2828625

2828626

2828630

2828633

2828637

2828638

2828639

2828640

2828641

2828642

2828644

2828645

2828648

2828649

2828651

2828654

2828655

2828656

2828657

2828683

2828685

39941_at

61032_at

75005_at

77975_r_at

8107942

86768_at

86770_at

A_14_P111032

A_14_P115082

A_14_P127472

A_24_P226198

A_24_P930707

GE60434

GO:0000003

GO:0000014

GO:0000019

GO:0000166

GO:0000228

GO:0000722

GO:0000723

GO:0000724

GO:0000729

GO:0000781

GO:0000784

GO:0000790

GO:0000794

GO:0003674

GO:0003677

GO:0003678

GO:0003691

GO:0004017

GO:0004386

GO:0004518

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0006259

GO:0006260

GO:0006281

GO:0006302

GO:0006303

GO:0006310

GO:0006464

GO:0006950

GO:0006974

GO:0007004

GO:0007049

GO:0007131

GO:0007165

GO:0008150

GO:0008408

GO:0009058

GO:0016020

GO:0016032

GO:0016233

GO:0016301

GO:0016787

GO:0016887

GO:0030674

GO:0030870

GO:0031860

GO:0031954

GO:0032206

GO:0032508

GO:0032991

GO:0033674

GO:0034641

GO:0035861

GO:0042592

GO:0042802

GO:0043047

GO:0043167

GO:0043226

GO:0044281

GO:0044403

GO:0046872

GO:0046940

GO:0051276

GO:0051321

GO:0051880

GO:0070192

GO:0090305

GO:1901796

GO:1904354

Hs.272173.0.A1_3p_at

ILMN_1708789

ILMN_1755023

PH_hs_0003079

TC05000639.hg

U63139_at

g1518805_3p_at

g5032016_3p_a_at

Participant Of

input

Formation of RAD50:MRE11 complex

hasComponent

Inferred To

Rad50 [nucleoplasm] (Mus musculus)

Rad50 [nucleoplasm] (Rattus norvegicus)

DNA repair protein RAD50 [nucleoplasm] (Saccharomyces cerevisiae)

rad-50 [nucleoplasm] (Caenorhabditis elegans)

RAD50 [nucleoplasm] (Bos taurus)

RAD50 [nucleoplasm] (Canis familiaris)

RAD50 [nucleoplasm] (Gallus gallus)

RAD50 [nucleoplasm] (Plasmodium falciparum)

RAD50 [nucleoplasm] (Sus scrofa)

RAD50 [nucleoplasm] (Xenopus tropicalis)

rad50 [nucleoplasm] (Danio rerio)

rad50 [nucleoplasm] (Dictyostelium discoideum)

rad50 [nucleoplasm] (Drosophila melanogaster)

rad50 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_005723.2

OpenTargets

ENSG00000113522

GeneCards

Q92878

HPA

ENSG00000113522-RAD50

Ensembl

ENST00000378823, ENSG00000113522, ENSP00000368100

PRO

Q92878

Orphanet

19459

PDB

5GOX

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49959 MRE11	2	MRE11A [nucleoplasm] (R-HSA-59544) MRE11A [cytosol] (R-HSA-3204309)	0.777	6
UniProt:O60934 NBN	3	NBN [nucleoplasm] (R-HSA-75163) NBN [cytosol] (R-HSA-5684005) p-S343-NBN [nucleoplasm] (R-HSA-75237)	0.712	4
UniProt:Q14676 MDC1	6	SUMO2,3-K1840-MDC1 [nucleoplasm] (R-HSA-4570473) SUMO1-K1840-MDC1 [nucleoplasm] (R-HSA-4570546) K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684074) SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684061) MDC1 [nucleoplasm] (R-HSA-75231) p-5T-MDC1 [nucleoplasm] (R-HSA-75236)	0.69	9
UniProt:Q92878 RAD50	1	RAD50 [nucleoplasm] (R-HSA-75160)	0.655	5
UniProt:Q9BXW9 FANCD2	3	p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6788481) FANCD2 [nucleoplasm] (R-HSA-419522) MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6785318)	0.578	4
UniProt:P46100 ATRX	138	ATRX K329Ifs3 [nucleoplasm] (R-HSA-9672232) ATRX E288 [nucleoplasm] (R-HSA-9670958) ATRX Q176* [nucleoplasm] (R-HSA-9671592) ATRX C268Qfs18 [nucleoplasm] (R-HSA-9672233) ATRX Q177 [nucleoplasm] (R-HSA-9671589) ATRX K330Nfs2 [nucleoplasm] (R-HSA-9672231) ATRX G161 [nucleoplasm] (R-HSA-9671266) ATRX Q176Hfs13 [nucleoplasm] (R-HSA-9671806) ATRX R160Pfs29 [nucleoplasm] (R-HSA-9671801) ATRX K319* [nucleoplasm] (R-HSA-9671669) ATRX W222* [nucleoplasm] (R-HSA-9671670) ATRX E63* [nucleoplasm] (R-HSA-9670961) ATRX S79* [nucleoplasm] (R-HSA-9671244) ATRX H166Mfs4 [nucleoplasm] (R-HSA-9672205) ATRX Y266 [nucleoplasm] (R-HSA-9671624) ATRX L253* [nucleoplasm] (R-HSA-9671688) ATRX W263* [nucleoplasm] (R-HSA-9671685) ATRX Y187* [nucleoplasm] (R-HSA-9671622) ATRX Y204* [nucleoplasm] (R-HSA-9671619) ATRX Q292* [nucleoplasm] (R-HSA-9671581) ATRX P190Hfs15 [nucleoplasm] (R-HSA-9672216) ATRX L274Ffs8 [nucleoplasm] (R-HSA-9671833) ATRX Q193* [nucleoplasm] (R-HSA-9671579) ATRX R188* [nucleoplasm] (R-HSA-9671637) ATRX S213* [nucleoplasm] (R-HSA-9671255) ATRX M205* [nucleoplasm] (R-HSA-9672215) ATRX L273Ffs9 [nucleoplasm] (R-HSA-9671825) ATRX R250 [nucleoplasm] (R-HSA-9671634) ATRX D184Ifs22 [nucleoplasm] (R-HSA-9672211) ATRX V478Ffs36 [nucleoplasm] (R-HSA-9672558) ATRX T534Wfs3 [nucleoplasm] (R-HSA-9672553) ATRX G859Rfs4 [nucleoplasm] (R-HSA-9672298) ATRX T792Ifs12 [nucleoplasm] (R-HSA-9672299) ATRX P995Tfs5 [nucleoplasm] (R-HSA-9672292) ATRX K994Efs6 [nucleoplasm] (R-HSA-9672294) ATRX I1049Nfs4 [nucleoplasm] (R-HSA-9672291) ATRX T387Qfs27 [nucleoplasm] (R-HSA-9672573) ATRX S471Vfs43 [nucleoplasm] (R-HSA-9672574) ATRX S558Ifs4 [nucleoplasm] (R-HSA-9672575) ATRX K358Nfs2 [nucleoplasm] (R-HSA-9672569) ATRX L639Wfs10 [nucleoplasm] (R-HSA-9672570) ATRX G551 [nucleoplasm] (R-HSA-9671290) ATRX G1071* [nucleoplasm] (R-HSA-9671291) ATRX K425Rfs8 [nucleoplasm] (R-HSA-9672564) ATRX E1010Mfs24 [nucleoplasm] (R-HSA-9672305) ATRX E991Gfs9 [nucleoplasm] (R-HSA-9672306) ATRX N428Yfs5 [nucleoplasm] (R-HSA-9672562) ATRX I360Rfs6 [nucleoplasm] (R-HSA-9672563) ATRX S1101 [nucleoplasm] (R-HSA-9671245) ATRX K1018Rfs5 [nucleoplasm] (R-HSA-9672270) ATRX S729 [nucleoplasm] (R-HSA-9671246) ATRX V957Sfs7 [nucleoplasm] (R-HSA-9672271) ATRX S567 [nucleoplasm] (R-HSA-9671243) ATRX R885Sfs21 [nucleoplasm] (R-HSA-9672284) ATRX S797 [nucleoplasm] (R-HSA-9671260) ATRX T844Yfs5 [nucleoplasm] (R-HSA-9672286) ATRX S788 [nucleoplasm] (R-HSA-9671257) ATRX R840Kfs9 [nucleoplasm] (R-HSA-9672276) ATRX S750 [nucleoplasm] (R-HSA-9671254) ATRX S342* [nucleoplasm] (R-HSA-9671250) ATRX C1122Lfs8 [nucleoplasm] (R-HSA-9672748) ATRX E431 [nucleoplasm] (R-HSA-9670957) ATRX E482* [nucleoplasm] (R-HSA-9670959) ATRX E643* [nucleoplasm] (R-HSA-9670952) ATRX K1081Rfs37 [nucleoplasm] (R-HSA-9672745) ATRX E1065 [nucleoplasm] (R-HSA-9670953) ATRX E1159* [nucleoplasm] (R-HSA-9670954) ATRX D1106Ifs12 [nucleoplasm] (R-HSA-9672747) ATRX E585 [nucleoplasm] (R-HSA-9670948) ATRX K1057Rfs61 [nucleoplasm] (R-HSA-9672741) ATRX E533 [nucleoplasm] (R-HSA-9670949) ATRX E680* [nucleoplasm] (R-HSA-9670950) ATRX D1126Rfs3 [nucleoplasm] (R-HSA-9672738) ATRX K1143Rfs47 [nucleoplasm] (R-HSA-9672739) ATRX D791* [nucleoplasm] (R-HSA-9672254) ATRX E625* [nucleoplasm] (R-HSA-9670964) ATRX L359Tfs3 [nucleoplasm] (R-HSA-9672244) ATRX P663Yfs10 [nucleoplasm] (R-HSA-9672247) ATRX E1119* [nucleoplasm] (R-HSA-9670960) ATRX R1128Sfs2 [nucleoplasm] (R-HSA-9672753) ATRX L359Hfs3 [nucleoplasm] (R-HSA-9672241) ATRX L452Ffs12 [nucleoplasm] (R-HSA-9672242) ATRX I383Nfs11 [nucleoplasm] (R-HSA-9672243) ATRX L664* [nucleoplasm] (R-HSA-9671689) ATRX L513* [nucleoplasm] (R-HSA-9671690) ATRX I1049* [nucleoplasm] (R-HSA-9672715) ATRX E976Dfs2 [nucleoplasm] (R-HSA-9672708) ATRX K1001Nfs3 [nucleoplasm] (R-HSA-9672709) ATRX K945Rfs25 [nucleoplasm] (R-HSA-9672711) ATRX I1049Kfs69 [nucleoplasm] (R-HSA-9672705) ATRX K826* [nucleoplasm] (R-HSA-9671681) ATRX T1172Lfs18 [nucleoplasm] (R-HSA-9672734) ATRX K459 [nucleoplasm] (R-HSA-9671660) ATRX K971Tfs31 [nucleoplasm] (R-HSA-9672686) ATRX K1052 [nucleoplasm] (R-HSA-9671656) ATRX K455* [nucleoplasm] (R-HSA-9671657) ATRX K983* [nucleoplasm] (R-HSA-9671659) ATRX E1017Dfs5 [nucleoplasm] (R-HSA-9672702) ATRX V1002 [nucleoplasm] (R-HSA-9672698) ATRX K782* [nucleoplasm] (R-HSA-9671674) ATRX K823* [nucleoplasm] (R-HSA-9671675) ATRX K967* [nucleoplasm] (R-HSA-9671668) ATRX K993Rfs10 [nucleoplasm] (R-HSA-9672695) ATRX K910 [nucleoplasm] (R-HSA-9671671) ATRX K1045* [nucleoplasm] (R-HSA-9671664) ATRX K562* [nucleoplasm] (R-HSA-9671665) ATRX I1049Mfs3 [nucleoplasm] (R-HSA-9672691) ATRX S871Hfs34 [nucleoplasm] (R-HSA-9672653) ATRX S784Lfs13 [nucleoplasm] (R-HSA-9672654) ATRX F888Sfs17 [nucleoplasm] (R-HSA-9672651) ATRX E886Dfs10 [nucleoplasm] (R-HSA-9672647) ATRX G859Efs10 [nucleoplasm] (R-HSA-9672643) ATRX R840Efs29 [nucleoplasm] (R-HSA-9672670) ATRX K823Rfs7 [nucleoplasm] (R-HSA-9672671) ATRX R781* [nucleoplasm] (R-HSA-9671640) ATRX Q883Rfs13 [nucleoplasm] (R-HSA-9672665) ATRX R666 [nucleoplasm] (R-HSA-9671636) ATRX A834Pfs35 [nucleoplasm] (R-HSA-9672662) ATRX R808 [nucleoplasm] (R-HSA-9671638) ATRX S876Lfs29 [nucleoplasm] (R-HSA-9672657) ATRX E886Lfs18 [nucleoplasm] (R-HSA-9672659) ATRX S747Rfs6 [nucleoplasm] (R-HSA-9672620) ATRX Q545 [nucleoplasm] (R-HSA-9671596) ATRX Q391* [nucleoplasm] (R-HSA-9671597) ATRX Q984* [nucleoplasm] (R-HSA-9671598) ATRX E723Dfs9 [nucleoplasm] (R-HSA-9672616) ATRX I737Kfs3 [nucleoplasm] (R-HSA-9672617) ATRX V725Gfs7 [nucleoplasm] (R-HSA-9672618) ATRX N676Kfs17 [nucleoplasm] (R-HSA-9672619) ATRX D774Mfs29 [nucleoplasm] (R-HSA-9672608) ATRX Q727 [nucleoplasm] (R-HSA-9671586) ATRX Y341* [nucleoplasm] (R-HSA-9671612) ATRX S747Ffs6 [nucleoplasm] (R-HSA-9672628) ATRX K778Nfs23 [nucleoplasm] (R-HSA-9672625) ATRX [nucleoplasm] (R-HSA-9007919) ATRX T684Sfs2 [nucleoplasm] (R-HSA-9672605) ATRX L738Gfs13 [nucleoplasm] (R-HSA-9672604) ATRX Q554Rfs*21 [nucleoplasm] (R-HSA-9672582)	0.537	5
UniProt:P16104 H2AX	7	Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [extracellular region] (R-HSA-977583) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) H2AFX [nucleoplasm] (R-HSA-56151)	0.527	3
UniProt:O95684 CEP43	3	FGFR1OP-p-FGFR1 fusion [cytosol] (R-HSA-1838994) FGFR1OP-FGFR1 fusion [cytosol] (R-HSA-1604533) FGFR1OP [cytosol] (R-HSA-380309)	0.527	2
UniProt:Q6NZQ4 Paxip1	2	Paxip1 [nucleoplasm] (R-MMU-5619395) Paxip1 [nucleoplasm] (R-MMU-5619398)	0.527	3
UniProt:O75943 RAD17	1	RAD17 [nucleoplasm] (R-HSA-3008665)	0.499	2
UniProt:Q12905 ILF2	4	ILF2 [specific granule lumen] (R-HSA-6799611) ILF2 [ficolin-1-rich granule lumen] (R-HSA-6801001) ILF2 [extracellular region] (R-HSA-6799684) ILF2 [tertiary granule lumen] (R-HSA-6800995)	0.462	3

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