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RAD50 [nucleoplasm]
Stable Identifier
R-HSA-75160
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser for interactor UniProt:Q9BXW9 FANCD2
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Sensing of DNA Double Strand Breaks (Homo sapiens)
Formation of RAD50:MRE11 complex (Homo sapiens)
RAD50 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92878 RAD50
Gene Names
RAD50
Chain
chain:1-1312
Reference Genes
BioGPS Gene:10111 RAD50
COSMIC (genes):RAD50 RAD50
CTD Gene:10111 RAD50
dbSNP Gene:10111 RAD50
ENSEMBL:ENSG00000113522 RAD50
HGNC:9816 RAD50
KEGG:hsa:10111 RAD50
Monarch:10111 RAD50
NCBI Gene:10111 RAD50
OMIM:604040 RAD50
UCSC:Q92878 RAD50
Reference Transcript
RefSeq:NM_005732.3 RAD50
Other Identifiers
10111
11730280_a_at
11730281_a_at
11730282_a_at
1533_at
16989054
208393_PM_s_at
208393_s_at
209349_PM_at
209349_at
238656_PM_at
238656_at
2828604
2828605
2828606
2828607
2828608
2828609
2828610
2828612
2828613
2828614
2828615
2828616
2828617
2828618
2828619
2828620
2828621
2828622
2828623
2828624
2828625
2828626
2828627
2828630
2828631
2828632
2828633
2828634
2828635
2828637
2828638
2828639
2828640
2828641
2828642
2828644
2828645
2828648
2828649
2828651
2828654
2828655
2828656
2828657
2828683
2828685
39941_at
61032_at
75005_at
77975_r_at
8107942
86768_at
86770_at
A_14_P111032
A_14_P115082
A_14_P127472
A_23_P250404
A_24_P226198
A_24_P930707
GE60434
GE695783
GO:0000014
GO:0000019
GO:0000228
GO:0000722
GO:0000723
GO:0000724
GO:0000729
GO:0000781
GO:0000794
GO:0003677
GO:0003678
GO:0003691
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0006281
GO:0006302
GO:0006310
GO:0006325
GO:0006974
GO:0007004
GO:0007131
GO:0008408
GO:0016020
GO:0016787
GO:0016887
GO:0022414
GO:0030674
GO:0030870
GO:0031860
GO:0031954
GO:0032200
GO:0032206
GO:0032508
GO:0033674
GO:0035825
GO:0035861
GO:0042802
GO:0043047
GO:0043226
GO:0043539
GO:0044818
GO:0046872
GO:0051321
GO:0051880
GO:0060090
GO:0062176
GO:0070192
GO:0070533
GO:0098687
GO:0098772
GO:0110025
GO:0140097
GO:0140657
GO:1904354
HMNXSV003032650
Hs.272173.0.A1_3p_at
ILMN_1708789
ILMN_1755023
PH_hs_0003079
TC05000639.hg
U63139_at
g1518805_3p_at
g5032016_3p_a_at
Participates
as a component of
MRN [nucleoplasm] (Homo sapiens)
RAD50:MRE11A [nucleoplasm] (Homo sapiens)
p-MRN [nucleoplasm] (Homo sapiens)
as an input of
Formation of RAD50:MRE11 complex (Homo sapiens)
Inferred To
DNA repair protein RAD50 [nucleoplasm]
(Saccharomyces cerevisiae)
Ghost homologue of RAD50 [nucleoplasm]
(Xenopus tropicalis)
RAD50 [nucleoplasm]
(Bos taurus)
RAD50 [nucleoplasm]
(Caenorhabditis elegans)
RAD50 [nucleoplasm]
(Canis familiaris)
RAD50 [nucleoplasm]
(Dictyostelium discoideum)
RAD50 [nucleoplasm]
(Drosophila melanogaster)
RAD50 [nucleoplasm]
(Gallus gallus)
RAD50 [nucleoplasm]
(Mus musculus)
RAD50 [nucleoplasm]
(Plasmodium falciparum)
RAD50 [nucleoplasm]
(Rattus norvegicus)
RAD50 [nucleoplasm]
(Schizosaccharomyces pombe)
RAD50 [nucleoplasm]
(Sus scrofa)
Cross References
RefSeq
NP_005723.2
ENSEMBL
ENSP00000368100
,
ENST00000378823
OpenTargets
ENSG00000113522
HPA
ENSG00000113522-RAD50
PRO
Q92878
Pharos - Targets
Q92878
GlyGen
Q92878
Orphanet
RAD50
PDB
5GOX
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49959 MRE11
2
MRE11A [nucleoplasm]
(R-HSA-59544)
MRE11A [cytosol]
(R-HSA-3204309)
0.777
6
UniProt:O60934 NBN
3
p-S343-NBN [nucleoplasm]
(R-HSA-75237)
NBN [cytosol]
(R-HSA-5684005)
NBN [nucleoplasm]
(R-HSA-75163)
0.712
4
UniProt:Q14676 MDC1
6
MDC1 [nucleoplasm]
(R-HSA-75231)
p-5T-MDC1 [nucleoplasm]
(R-HSA-75236)
SUMO2-K1840,p-5T-MDC1 [nucleoplasm]
(R-HSA-5684061)
K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm]
(R-HSA-5684074)
polySUMO2,3-K1840-MDC1 [nucleoplasm]
(R-HSA-4570473)
monoSUMO1-K1840-MDC1 [nucleoplasm]
(R-HSA-4570546)
0.671
9
UniProt:Q92878 RAD50
1
RAD50 [nucleoplasm]
(R-HSA-75160)
0.655
5
UniProt:O95684 CEP43
3
FGFR1OP(2-163)-FGFR1(429-822) fusion [cytosol]
(R-HSA-1604533)
FGFR1OP(2-163)-p-FGFR1(429-822) fusion [cytosol]
(R-HSA-1838994)
FGFR1OP [cytosol]
(R-HSA-380309)
0.615
3
UniProt:P41235 HNF4A
1
HNF4A [nucleoplasm]
(R-HSA-446162)
0.604
3
UniProt:Q9BXW9 FANCD2
3
FANCD2 [nucleoplasm]
(R-HSA-419522)
p-T691,S717-FANCD2 [nucleoplasm]
(R-HSA-6788481)
MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm]
(R-HSA-6785318)
0.578
4
UniProt:P46100 ATRX
20
ATRX E288* [nucleoplasm]
(R-HSA-9670958)
ATRX K329Ifs*3 [nucleoplasm]
(R-HSA-9672232)
ATRX Q176* [nucleoplasm]
(R-HSA-9671592)
ATRX C268Qfs*18 [nucleoplasm]
(R-HSA-9672233)
ATRX Q177* [nucleoplasm]
(R-HSA-9671589)
ATRX K330Nfs*2 [nucleoplasm]
(R-HSA-9672231)
ATRX G161* [nucleoplasm]
(R-HSA-9671266)
ATRX Q176Hfs*13 [nucleoplasm]
(R-HSA-9671806)
ATRX R160Pfs*29 [nucleoplasm]
(R-HSA-9671801)
ATRX K319* [nucleoplasm]
(R-HSA-9671669)
ATRX W222* [nucleoplasm]
(R-HSA-9671670)
ATRX E63* [nucleoplasm]
(R-HSA-9670961)
ATRX S79* [nucleoplasm]
(R-HSA-9671244)
ATRX H166Mfs*4 [nucleoplasm]
(R-HSA-9672205)
ATRX Y266* [nucleoplasm]
(R-HSA-9671624)
ATRX L253* [nucleoplasm]
(R-HSA-9671688)
ATRX W263* [nucleoplasm]
(R-HSA-9671685)
ATRX Y187* [nucleoplasm]
(R-HSA-9671622)
ATRX Y204* [nucleoplasm]
(R-HSA-9671619)
ATRX Q292* [nucleoplasm]
(R-HSA-9671581)
0.537
5
UniProt:Q6NZQ4 Paxip1
2
Paxip1 [nucleoplasm]
(R-MMU-5619398)
Paxip1 [nucleoplasm]
(R-MMU-5619395)
0.527
3
UniProt:P16104 H2AFX
7
H2AFX [nucleoplasm]
(R-HSA-56151)
p-Y143-H2AFX [nucleoplasm]
(R-HSA-5683942)
p-S140,Y143-H2AFX [nucleoplasm]
(R-HSA-5683953)
p-S140-H2AFX [nucleoplasm]
(R-HSA-75170)
K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm]
(R-HSA-5682847)
H2AFX [extracellular region]
(R-HSA-977583)
Me2sR4-H2AFX [nucleoplasm]
(R-HSA-5218317)
0.527
3
UniProt:Q6P656 CF161
0.508
2
UniProt:O75943 RAD17
1
RAD17 [nucleoplasm]
(R-HSA-3008665)
0.499
2
UniProt:Q12905 ILF2
5
ILF2 [cytosol]
(R-HSA-9836392)
ILF2 [specific granule lumen]
(R-HSA-6799611)
ILF2 [extracellular region]
(R-HSA-6799684)
ILF2 [tertiary granule lumen]
(R-HSA-6800995)
ILF2 [ficolin-1-rich granule lumen]
(R-HSA-6801001)
0.462
3
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