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MRN [nucleoplasm]
Stable Identifier
R-HSA-75164
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
MRE11:RAD50:NBS1, MRE11:RAD50:NBN
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic recombination (Homo sapiens)
MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11 (Homo sapiens)
MRN:CtIP [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end (Homo sapiens)
MRN:CtIP [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
KAT5 acetylates ATM at DNA DSBs (Homo sapiens)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
KAT5 acetylates ATM at shortened telomeres (Homo sapiens)
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
Shortened telomere:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
Shortened telomere:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
MRN activates ATM (Homo sapiens)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
MRN bound to shortened telomeres activates ATM (Homo sapiens)
Shortened telomere:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
Shortened telomere:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
Shortened telomere:MRN:KAT5:p-S1981,Ac-K3016-ATM [nucleoplasm] (Homo sapiens)
Shortened telomere:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
MRN complex binds DNA double strand breaks (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
MRN complex binds shortened telomeres (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
Shortened telomere:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
MRN complex bound to DNA ends recruits ATM (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
MRN complex bound to shortened telomeres recruits ATM (Homo sapiens)
Shortened telomere:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
Shortened telomere:MRN:ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
Shortened telomere:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
ATM phosphorylates NBN (Homo sapiens)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
Sensing of DNA Double Strand Breaks (Homo sapiens)
Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
KAT5 acetylates ATM at DNA DSBs (Homo sapiens)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
MRN activates ATM (Homo sapiens)
DNA DSBs:MRN:Ac-K3016-ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
MRN complex binds DNA double strand breaks (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
MRN complex bound to DNA ends recruits ATM (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN:ATM dimer:KAT5 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through MMEJ (alt-NHEJ) (Homo sapiens)
FEN1 cleaves displaced ssDNA flaps during MMEJ (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
LIG3 ligates remaining SSBs in MMEJ (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
MRN and RBBP8 resect DNA DSBs in MMEJ (Homo sapiens)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Homo sapiens)
Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
MRN complex binds RBBP8 (Homo sapiens)
DNA DSB:MRN:RBBP8 [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
MRN recruits LIG3:XRCC1 to MMEJ sites (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:LIG3:XRCC1 [nucleoplasm] (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
PARP1 or PARP2, FEN1 and POLQ are recruited to MMEJ site (Homo sapiens)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Homo sapiens)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Homo sapiens)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
Microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Homo sapiens)
Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
PARP1,PARP2 dimers bound to MMEJ sites autoPARylate (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:FEN1 [nucleoplasm] (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
POLQ extends annealed 3'-ssDNA overhangs in MMEJ (Homo sapiens)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Homo sapiens)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN:RBBP8 [nucleoplasm] (Homo sapiens)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8:PARP1,PARP2:FEN1:POLQ [nucleoplasm] (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN:RBBP8 [nucleoplasm] (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
Reproduction (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic recombination (Homo sapiens)
MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11 (Homo sapiens)
MRN:CtIP [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end (Homo sapiens)
MRN:CtIP [nucleoplasm] (Homo sapiens)
MRN [nucleoplasm] (Homo sapiens)
Participants
components
MRE11A [nucleoplasm]
(Homo sapiens)
NBN [nucleoplasm]
(Homo sapiens)
RAD50 [nucleoplasm]
(Homo sapiens)
Participates
as a component of
MRN:CtIP [nucleoplasm] (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Homo sapiens)
Microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Homo sapiens)
Annealed microhomologous 3'-ssDNA overhangs-DSB:MRN [nucleoplasm] (Homo sapiens)
Extended microhomologous 3'-ssDNA overhangs-flap-DSB:MRN [nucleoplasm] (Homo sapiens)
Shortened telomere:MRN [nucleoplasm] (Homo sapiens)
DNA DSBs:MRN [nucleoplasm] (Homo sapiens)
as an output of
LIG3 ligates remaining SSBs in MMEJ (Homo sapiens)
Association of RAD50:MRE11A complex with NBN (NBS1) via MRE11A interaction (Homo sapiens)
as an input of
MRN complex binds shortened telomeres (Homo sapiens)
MRN complex binds DNA double strand breaks (Homo sapiens)
Inferred To
MRN [nucleoplasm]
(Bos taurus)
MRN [nucleoplasm]
(Caenorhabditis elegans)
MRN [nucleoplasm]
(Canis familiaris)
MRN [nucleoplasm]
(Dictyostelium discoideum)
MRN [nucleoplasm]
(Drosophila melanogaster)
MRN [nucleoplasm]
(Gallus gallus)
MRN [nucleoplasm]
(Mus musculus)
MRN [nucleoplasm]
(Rattus norvegicus)
MRN [nucleoplasm]
(Saccharomyces cerevisiae)
MRN [nucleoplasm]
(Schizosaccharomyces pombe)
MRN [nucleoplasm]
(Sus scrofa)
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