TRAIL:TRAIL receptor trimers bind FADD

Stable Identifier
R-HSA-75187
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The trimeric complex of TRAIL and TRAIL receptor-1 (TNFSF10:TNFRSF10A) or TRAIL receptor-2 (TNFSF10:TNFRSF10B) binds FADD (Sprick et al. 2000).

Literature References
PubMed ID Title Journal Year
10894160 FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

Sprick, MR, Weigand, MA, Rieser, E, Rauch, CT, Juo, P, Blenis, J, Krammer, PH, Walczak, H

Immunity 2000
17327223 Receptor-mediated endocytosis is not required for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis

Kohlhaas, SL, Craxton, A, Sun, XM, Pinkoski, MJ, Cohen, GM

J. Biol. Chem. 2007
Participants
Participant Of
hasEvent
This event is regulated
Negatively by
Orthologous Events
Reviewed
Created