Reactome | Phosphorylation of Cdc25C at Ser216 by CHEK2

Phosphorylation of Cdc25C at Ser216 by CHEK2

Stable Identifier

R-HSA-75809

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

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Phosphorylation of Cdc25C at Ser216 by CHEK2

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Cdc25C is negatively regulated by phosphorylation on Ser 216, the 14-3-3-binding site. This is an important regulatory mechanism used by cells to block mitotic entry under normal conditions and after DNA damage (Chaturvedi et al, 1999; Bulavin et al., 2003).

Literature References

PubMed ID	Title	Journal	Year
12766774	Dual phosphorylation controls Cdc25 phosphatases and mitotic entry Bulavin, DV, Higashimoto, Y, Demidenko, ZN, Meek, S, Graves, P, Phillips, C, Zhao, H, Moody, SA, Appella, E, Piwnica-Worms, H, Fornace AJ, Jr	Nat Cell Biol	2003
10435585	Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway Chaturvedi, P, Eng, WK, Zhu, Y, Mattern, MR, Mishra, R, Hurle, MR, Zhang, X, Annan, RS, Lu, Q, Faucette, LF, Scott, GF, Li, X, Carr, SA, Johnson, RK, Winkler, JD, Zhou, BB	Oncogene	1999