Reactome: A Curated Pathway Database

Phosphorylation of Cdc25C at Ser216 by CHEK2

Stable Identifier
R-HSA-75809
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cdc25C is negatively regulated by phosphorylation on Ser 216, the 14-3-3-binding site. This is an important regulatory mechanism used by cells to block mitotic entry under normal conditions and after DNA damage (Chaturvedi et al, 1999; Bulavin et al., 2003).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
kinase activity of p-S,3T-CHEK2 [nucleoplasm] p-S,3T-CHEK2 [nucleoplasm] kinase activity (0016301)
Orthologous Events