Phosphorylation of Cdc25C at Ser216 by CHEK2

Stable Identifier
Reaction [transition]
Homo sapiens
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Cdc25C is negatively regulated by phosphorylation on Ser 216, the 14-3-3-binding site. This is an important regulatory mechanism used by cells to block mitotic entry under normal conditions and after DNA damage (Chaturvedi et al, 1999; Bulavin et al., 2003).

Literature References
PubMed ID Title Journal Year
12766774 Dual phosphorylation controls Cdc25 phosphatases and mitotic entry

Bulavin, DV, Higashimoto, Y, Demidenko, ZN, Meek, S, Graves, P, Phillips, C, Zhao, H, Moody, SA, Appella, E, Piwnica-Worms, H, Fornace AJ, Jr

Nat Cell Biol 2003
10435585 Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway

Chaturvedi, P, Eng, WK, Zhu, Y, Mattern, MR, Mishra, R, Hurle, MR, Zhang, X, Annan, RS, Lu, Q, Faucette, LF, Scott, GF, Li, X, Carr, SA, Johnson, RK, Winkler, JD, Zhou, BB

Oncogene 1999
Catalyst Activity

protein serine/threonine kinase activity of p-S,3T-CHEK2 [nucleoplasm]

Orthologous Events
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