Reactome: A Curated Pathway Database

Phosphorylation of Cdc25C at Ser216 by CHEK2

Stable Identifier
R-HSA-75809
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Summation

Cdc25C is negatively regulated by phosphorylation on Ser 216, the 14-3-3-binding site. This is an important regulatory mechanism used by cells to block mitotic entry under normal conditions and after DNA damage (Chaturvedi et al, 1999; Bulavin et al., 2003).

Literature References
PubMed ID Title Journal Year
12766774 Dual phosphorylation controls Cdc25 phosphatases and mitotic entry Nat Cell Biol 2003
10435585 Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway Oncogene 1999
Participants
input
output
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
kinase activity of p-S,3T-CHEK2 [nucleoplasm] p-S,3T-CHEK2 [nucleoplasm] kinase activity (0016301)
Orthologous Events
 
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