Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta

Stable Identifier
R-HSA-75820
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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At the beginning of this reaction, 1 molecule of 'Cyclin D1:Cdk4', and 1 molecule of 'ATP' are present. At the end of this reaction, 1 molecule of 'phospho(T286)-Cyclin D1:Cdk4', and 1 molecule of 'ADP' are present.

This reaction takes place in the 'nucleus' and is mediated by the 'kinase activity' of 'glycogen synthase kinase-3 beta'.

Literature References
PubMed ID Title Journal Year
16732330 Identification of mutations that disrupt phosphorylation-dependent nuclear export of cyclin D1

Benzeno, S, Lu, F, Guo, M, Barbash, O, Zhang, F, Herman, JG, Klein, PS, Rustgi, A, Diehl, JA

Oncogene 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of GSK3B [nucleoplasm]
Physical Entity
Activity
Inferred From
Created