Proteasome mediated degradation of Cyclin D1

Stable Identifier
R-HSA-75825
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Phosphorylated Cyclin D1 is degraded during S phase by the 26S proteasome allowing for efficient DNA synthesis.

Literature References
PubMed ID Title Journal Year
15735756 Phosphorylation of cyclin D1 at Thr 286 during S phase leads to its proteasomal degradation and allows efficient DNA synthesis

Guo, Y, Yang, K, Harwalkar, J, Nye, JM, Mason, DR, Garrett, MD, Hitomi, M, Stacey, DW

Oncogene 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Orthologous Events