acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O

Stable Identifier
R-HSA-75872
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Conversion of malonyl-CoA and acetyl-CoA to palmitate
Locations in the PathwayBrowser
Summation

Cytosolic fatty acid synthase (FAS) complex catalyzes the reaction of acetyl-CoA with 7 malonyl-CoA and 14 NADHP + 14 H+ to form a molecule of palmitate and 7 CO2, 14 NADP+, 8 CoASH, and 6 H2O. The process proceeds via the successive condensations of malonyl groups onto the growing acyl chain,each followed by loss of CO2 and three steps of reduction (Smith et al. 2003).

Literature References
PubMed ID Title Journal Year
12689621 Structural and functional organization of the animal fatty acid synthase. Prog Lipid Res 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
fatty acid synthase activity of FASN dimer [cytosol]
Physical Entity
Activity
Orthologous Events