DHAP is converted to G3P by GPD1/GPD1L

Stable Identifier
R-HSA-75889
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Conversion of Dihydroxyacetone Phosphate to Glycerol -3- phosphate
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Dihydroxyacetone phosphate (DHAP) is converted to glycerol-3-phosphate (G3P) by glycerol-3-phosphate dehydrogenase (GPD1) or by glycerol-3-phosphate dehydrogenase-like (GPD1L) enzymes (Ou et al. 2006, Valdivia et al. 2009). The active forms of both enzymes are homodimers. This reaction may be found in white adipose tissues where glycerol-3-kinase activity is not observed in sufficient levels. GPD1/GPD1L reduces dihydroxyacetone phosphate with NADH donating electrons to this reduction.

Literature References
PubMed ID Title Journal Year
19666841 GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5A

Valdivia, CR, Ueda, K, Ackerman, MJ, Makielski, JC

Am J Physiol Heart Circ Physiol 2009
16460752 Crystal structures of human glycerol 3-phosphate dehydrogenase 1 (GPD1)

Ou, X, Ji, C, Han, X, Zhao, X, Li, X, Mao, Y, Wong, LL, Bartlam, M, Rao, Z

J Mol Biol 2006
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
glycerol-3-phosphate dehydrogenase [NAD+] activity of GPD1/GPD1L homodimer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Created