Reactome | XRCC4 [nucleoplasm]

XRCC4 [nucleoplasm]

Stable Identifier

R-HSA-75911

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

DNA repair protein XRCC4

Locations in the PathwayBrowser for interactor UniProt:O15499 GSC2

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External Reference Information

External Reference

UniProt:Q13426 XRCC4

Gene Names

XRCC4

Chain

chain:1-336, chain:266-336

Reference Genes

BioGPS Gene:7518 XRCC4

COSMIC (genes):XRCC4 XRCC4

CTD Gene:7518 XRCC4

dbSNP Gene:7518 XRCC4

ENSEMBL:ENSG00000152422 XRCC4

HGNC:12831 XRCC4

KEGG:hsa:7518 XRCC4

Monarch:7518 XRCC4

NCBI Gene:7518 XRCC4

OMIM:194363 XRCC4

UCSC:Q13426 XRCC4

Reference Transcript

Participates

as an input of

PIAS1,2-1 SUMOylates XRCC4 with SUMO1 (Homo sapiens)

as a component of

XRCC4 homodimer [nucleoplasm] (Homo sapiens)

Other forms of this molecule

monoSUMO1-K210-XRCC4 [nucleoplasm]

Inferred To

Xrcc4 [nucleoplasm] (Mus musculus)

Xrcc4 [nucleoplasm] (Rattus norvegicus)

XRCC4 [nucleoplasm] (Bos taurus)

XRCC4 [nucleoplasm] (Canis familiaris)

XRCC4 [nucleoplasm] (Gallus gallus)

xrcc4 [nucleoplasm] (Dictyostelium discoideum)

xrcc4 [nucleoplasm] (Xenopus tropicalis)

Dmel\CG3448 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of XRCC4 [nucleoplasm] (Sus scrofa)

Cross References

ENSEMBL

ENST00000282268, ENSP00000421491, ENSP00000282268, ENST00000396027, ENSP00000342011, ENSP00000379344, ENSG00000152422, ENST00000511817, ENST00000338635

OpenTargets

ENSG00000152422

HPA

ENSG00000152422-XRCC4

GeneCards

XRCC4

PRO

Q13426

Pharos - Targets

Q13426

Orphanet

XRCC4

PDB

5WLZ, 5E50, 3Q4F, 3MUD, 3W03, 7LSY, 3RWR, 5CJ0, 6ABO, 5CJ4, 8EZA, 8BH3, 8EZB, 7LT3, 8BOT, 3SR2, 7NFE, 7NFC, 1FU1, 4XA4, 8BHV, 5WJ7, 8BHY, 3II6, 7M3P, 1IK9, 5CHX

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49917 LIG4	1	LIG4 [nucleoplasm] (R-HSA-53791)	0.964	22
UniProt:Q96T60 PNKP	1	PNKP [nucleoplasm] (R-HSA-5649651)	0.942	18
UniProt:Q9H9Q4 NHEJ1	1	NHEJ1 [nucleoplasm] (R-HSA-5687247)	0.868	11
UniProt:Q13426 XRCC4	2	XRCC4 [nucleoplasm] (R-HSA-75911) monoSUMO1-K210-XRCC4 [nucleoplasm] (R-HSA-4568892)	0.844	7
UniProt:Q8IW19 APLF			0.844	6
UniProt:Q8IZU0 FAM9B			0.831	9
UniProt:Q7Z2E3 APTX			0.785	6
UniProt:Q0D2I5 IFFO1			0.771	7
UniProt:P12956 XRCC6	5	XRCC6 [nucleoplasm] (R-HSA-58272) XRCC6 [cytosol] (R-HSA-3134813) XRCC6 [ficolin-1-rich granule lumen] (R-HSA-6801300) XRCC6 [extracellular region] (R-HSA-6806444) XRCC6 [secretory granule lumen] (R-HSA-6801312)	0.656	3
UniProt:Q9H9Q4-1 NHEJ1			0.642	4
UniProt:O00499 BIN1	1	BIN1 [cytosol] (R-HSA-8868265)	0.625	4
UniProt:Q0D2I5-5 IFFO1			0.591	4
UniProt:Q13426-3 XRCC4			0.556	3
UniProt:O15499 GSC2			0.556	3
UniProt:Q9NVX0 HAUS2	1	HAUS2 [cytosol] (R-HSA-380274)	0.556	3
UniProt:Q2TB18 ASTE1			0.556	3
UniProt:Q7Z3Y8 KRT27	1	KRT27 [cytosol] (R-HSA-6809587)	0.556	3
UniProt:P43360 MAGA6			0.556	3
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.527	3
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cytosol] (R-HSA-195263) CSNK1A1 [cilium] (R-HSA-5632507)	0.527	2
UniProt:Q5TF58 IFFO2			0.527	4
UniProt:Q9NP50 SHCAF			0.527	2
UniProt:Q8IUD6 RNF135	1	RNF135 [cytosol] (R-HSA-936042)	0.527	2
UniProt:Q1L5Z9 LONF2			0.527	3
UniProt:P63167 DYNLL1	6	DYNLL1 [cytosol] (R-HSA-387105) DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [cilium] (R-HSA-5624863) DYNLL1 [ciliary tip] (R-HSA-5625335)	0.527	2
UniProt:Q92624 APBP2			0.527	3
UniProt:Q96QD9 FYTTD1	1	FYTTD1 [nucleoplasm] (R-HSA-8852176)	0.527	2
UniProt:Q96FJ2 DYNLL2	4	DYNLL2 [cytosol] (R-HSA-2029024) DYNLL2 [plasma membrane] (R-HSA-140527) DYNLL2 [cilium] (R-HSA-5624865) DYNLL2 [ciliary tip] (R-HSA-5625337)	0.527	2
UniProt:Q96SD1 DCLRE1C	3	DCLRE1C [nucleoplasm] (R-HSA-5686712) p-S645-DCLRE1C [nucleoplasm] (R-HSA-5686708) p-S516,S645-DCLRE1C [nucleoplasm] (R-HSA-5687176)	0.462	3

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