Negative supercoiling in the promoter region probably induces transient opening events and can alleviate requirement of TFIIE, TFIIH and ATP-hydrolysis for open complex formation. ATP is also used in this step by the cdk7-subunit of TFIIH to phosphorylate the heptad repeats of the C-terminal domain of the largest subunit of RNA polymerase II (RPB1) on serine-2
Coin, F, Egly, JM, Tirode, F, Busso, D
Bunick, D, Zandomeni, R, Ackerman, S, Weinmann, R
Sharp, PA, Parvin, JD
Fiedler, U, Marc Timmers, HT
Goodrich, JA, Tjian, R
Gralla, JD, Carey, M, Wang, W
Fiedler, U, Timmers, HT, Holstege, FC
Orphanides, G, Reinberg, D, Lagrange, T
3'-5' DNA helicase activity of TFIIH [nucleoplasm]
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