RNA Polymerase III Transcription Initiation From Type 1 Promoter

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R-HSA-76061
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Homo sapiens
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The type 1 promoters recruit TFIIIA, the founding member of the C2H2 zinc finger family of DNA-binding proteins (Engelke et al., 1980; Sakonju et al., 1981). The binding of TFIIIA then allows the binding of TFIIC (Lassar et al., 1983), a complex consisting of five subunits (which differs from the six subunits in S. cerevisiae) in human cells and S. pombe. Once the DNA/TFIIIA/TFIIIC complex is formed, Brf1-TFIIIB joins the complex and this in turn allows the recruitment of RNA polymerase III (Bieker et al., 1985; Setzer and Brown, 1985).

Literature References
PubMed ID Title Journal Year
3967290 Formation of a rate-limiting intermediate in 5S RNA gene transcription

Bieker, JJ, Martin, PL, Roeder, RG

Cell 1985
3972795 Formation and stability of the 5 S RNA transcription complex

Setzer, DR, Brown, DD

J Biol Chem 1985
6356356 Transcription of class III genes: formation of preinitiation complexes

Lassar, AB, Martin, PL, Roeder, RG

Science 1983
7226225 The binding of a transcription factor to deletion mutants of a 5S ribosomal RNA gene

Sakonju, S, Brown, DD, Engelke, D, Ng, SY, Shastry, BS, Roeder, RG

Cell 1981
6153931 Specific interaction of a purified transcription factor with an internal control region of 5S RNA genes

Engelke, DR, Ng, SY, Shastry, BS, Roeder, RG

Cell 1980
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