N-hydroxylation of 4-aminobiphenyl

Stable Identifier
R-HSA-76373
Type
Reaction
Species
Homo sapiens
Compartment
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Heterocyclic and aromatic amines require metabolic activation to convert them to genotoxic metabolites.The initial step is N-hydroxylation and cytochrome P450 1A2 can carry out the catalysis.

Literature References
PubMed ID Title Journal Year
9111224 Metabolism of carcinogenic heterocyclic and aromatic amines by recombinant human cytochrome P450 enzymes

Hammons, GJ, Milton, D, Stepps, K, Guengerich, FP, Tukey, RH, Kadlubar, FF

Carcinogenesis 1997
1934265 Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon

Turesky, RJ, Lang, NP, Butler, MA, Teitel, CH, Kadlubar, FF

Carcinogenesis 1991
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of CYP1A2 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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