CYP1A2 S-demethylates 6MMP

Stable Identifier
R-HSA-76386
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
S-atom dealkylation of 6-methylmercaptopurine
ReviewStatus
5/5
Locations in the PathwayBrowser
General
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At the beginning of this reaction, 1 molecule of 'H+', 1 molecule of '6-Methylmercaptopurine', 1 molecule of 'Oxygen', and 1 molecule of 'NADPH' are present. At the end of this reaction, 1 molecule of 'NADP+', 1 molecule of '6-Mercaptopurine', 1 molecule of 'Formaldehyde', and 1 molecule of 'H2O' are present.

This reaction takes place in the 'smooth endoplasmic reticulum' and is mediated by the 'oxygen binding activity' of 'Cytochrome P450 1A2 '.
Literature References
PubMed ID Title Journal Year
  Casarett and Doull's Toxicology 5th Edn

Parkinson, A

  1995
Participants
Participates
Catalyst Activity

monooxygenase activity of CYP1A2 [endoplasmic reticulum membrane]

Orthologous Events
Created
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