Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)

Stable Identifier
R-HSA-76397
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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N-acetyl-p-benzoquinone imine (NAPQI) is the reactive intermediate of the analgesic and antipyretic, acetaminophen (INN, paracetamol). At usual doses, NAPQI is quickly detoxified by conjugation but in overdose situations, NAPQI is extremely toxic to liver tissue.
Literature References
PubMed ID Title Journal Year
10741631 Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation

Kharasch, ED, Slattery, JT, Kalhorn, TF, Manyike, PT

Clin Pharmacol Ther 2000
Participants
Participates
Event Information
Catalyst Activity

monooxygenase activity of Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane]

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