Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)

Stable Identifier
R-HSA-76397
Type
Reaction
Species
Homo sapiens
Compartment
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N-acetyl-p-benzoquinone imine (NAPQI) is the reactive intermediate of the analgesic and antipyretic, acetaminophen (INN, paracetamol). At usual doses, NAPQI is quickly detoxified by conjugation but in overdose situations, NAPQI is extremely toxic to liver tissue.

Literature References
PubMed ID Title Journal Year
10741631 Contribution of CYP2E1 and CYP3A to acetaminophen reactive metabolite formation

Manyike, PT, Kharasch, ED, Kalhorn, TF, Slattery, JT

Clin Pharmacol Ther 2000
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Catalyst Activity
Title
monooxygenase activity of Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane]
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Activity
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