Benzene is hydroxylated to phenol

Stable Identifier
R-HSA-76416
Type
Reaction [transition]
Species
Homo sapiens
Compartment
smooth endoplasmic reticulum
Synonyms
Benzene + O2 + NADPH + H+ -> Phenol + H2O + NADP+
ReviewStatus
5/5
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Benzene is hydroxylated to phenol
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Benzene is an occupational and environmental toxicant and is implicated in myelogenous leukemia. For toxicity to occur, benzene is oxidised to phenol and subsequently to catechol and hydroquinone. CYP2E1 is the enzyme responsible for oxidation of benzene to phenol.
Literature References
PubMed ID Title Journal Year
11701230 Cytochrome P450 isozymes involved in the metabolism of phenol, a benzene metabolite

Carlson, GP, Powley, MW

Toxicol Lett 2001
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Output
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as an event of
Event Information
Go Biological Process
benzene metabolic process (0018910)
Catalyst Activity

monooxygenase activity of Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane]

Physical Entity
Cytochrome P450 (CYP2E1 based) [endoplasmic reticulum membrane] (Homo sapiens)
Activity
monooxygenase activity (GO:0004497)
Orthologous Events
Benzene is hydroxylated to phenol (Bos taurus)
Benzene is hydroxylated to phenol (Caenorhabditis elegans)
Benzene is hydroxylated to phenol (Canis familiaris)
Benzene is hydroxylated to phenol (Danio rerio)
Benzene is hydroxylated to phenol (Dictyostelium discoideum)
Benzene is hydroxylated to phenol (Drosophila melanogaster)
Benzene is hydroxylated to phenol (Gallus gallus)
Benzene is hydroxylated to phenol (Mus musculus)
Benzene is hydroxylated to phenol (Rattus norvegicus)
Benzene is hydroxylated to phenol (Sus scrofa)
Benzene is hydroxylated to phenol (Xenopus tropicalis)
Authored
Jassal, B  (2008-05-19)
Reviewed
D'Eustachio, P  (2008-05-28)
Created
Jassal, B  (2003-08-05)
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