Coumarin is 7-hydroxylated by CYP2A6

Stable Identifier
R-HSA-76453
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The 7-hydroxylation of coumarin is used as an assay of P450 activity in animal and human liver microsomes. CYP2A6 is the major coumarin 7-hydroxylase in human liver.

Literature References
PubMed ID Title Journal Year
15665333 Kinetic analysis of oxidation of coumarins by human cytochrome P450 2A6

Yun, CH, Kim, KH, Calcutt, MW, Guengerich, FP

J Biol Chem 2005
Participants
Participant Of
hasEvent
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
coumarin 7-hydroxylase activity of Cytochrome P450 (CYP2A3 based) [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created