Ethylene is oxidized to Ethylene oxide by CYP1A1

Stable Identifier
R-HSA-76472
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Ethylene oxidized to Ethylene oxide
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A simple example of epoxidation is the oxidation of an alkene (olefin) to the epoxide (oxirane), catalysed by CYP1A1. Even the simplest of epoxides (ethylene oxide) can react with DNA and amino groups in a protein.

Literature References
PubMed ID Title Journal Year
12464245 Cytochrome P450 oxidations in the generation of reactive electrophiles: epoxidation and related reactions

Guengerich, FP

Arch Biochem Biophys 2003
7217086 Destruction of cytochrome P-450 by ethylene. Structure of the resulting prosthetic heme adduct.

Ortiz, de Montell, Beilan, HS, Kunze, KL, Mico, BA

J Biol Chem 1981
Participants
Participant Of
hasEvent
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of CYP1A1 [endoplasmic reticulum membrane]
Physical Entity
Activity
This event is regulated
Negatively by
Orthologous Events
Authored
Reviewed
Created