TBXAS1 isomerises PGH2 to TXA2

Stable Identifier
R-HSA-76500
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, endoplasmic reticulum lumen
Synonyms
Thromboxane synthase (CYP5A1) mediates the isomerization of prostaglandin H2 to thromboxane A2
ReviewStatus
5/5
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TBXAS1 isomerises PGH2 to TXA2
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Thromboxane synthase (TBXAS1) aka CYP5A1 mediates the isomerisation of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2) (Miyata et al. 2001, Chevalier et al. 2001). This reaction is not coupled with any P450 reductase proteins nor consumes NADPH.
Literature References
PubMed ID Title Journal Year
7925341 Characterization of the human gene (TBXAS1) encoding thromboxane synthase

Ihara, H, Takahashi, E, Yokoyama, C, Miyata, A, Bandoh, S, Tanabe, T, Takeda, O

Eur J Biochem 1994
11465543 Identification of genetic variants in the human thromboxane synthase gene (CYP5A1)

Allorge, D, Lhermitte, M, Lo-Guidice, JM, Chevalier, D, Debuysère, H, Ferrari, N, Sergent, E, Libersa, C, Broly, F

Mutat Res 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

thromboxane-A synthase activity of TBXAS1 [endoplasmic reticulum membrane]

Physical Entity
TBXAS1 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
thromboxane-A synthase activity (GO:0004796)
Orthologous Events
TBXAS1 isomerises PGH2 to TXA2 (Bos taurus)
TBXAS1 isomerises PGH2 to TXA2 (Canis familiaris)
TBXAS1 isomerises PGH2 to TXA2 (Gallus gallus)
TBXAS1 isomerises PGH2 to TXA2 (Mus musculus)
TBXAS1 isomerises PGH2 to TXA2 (Rattus norvegicus)
TBXAS1 isomerises PGH2 to TXA2 (Sus scrofa)
Cross References
Rhea
Authored
Jassal, B  (2008-10-01)
Reviewed
Rush, MG  (2012-11-10)
Created
Jassal, B  (2003-08-05)
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