AMP + H2O => IMP + NH4+ (AMPD)

Stable Identifier
R-HSA-76590
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic AMP deaminase (AMPD) catalyzes the hydrolysis of AMP to yield IMP and ammonia. Three isoforms of AMPD, E, L, and M, have been identified that differ in their expression patterns in the body. All occur as tetramers and all have qualitatively the same catalytic activity, however (Bausch-Jurken et al. 1992; Mahnke-Zizelman et al. 1998).

Literature References
PubMed ID Title Journal Year
9857047 Novel aspects of tetramer assembly and N-terminal domain structure and function are revealed by recombinant expression of human AMP deaminase isoforms

Mahnke-Zizelman, DK, Tullson, PC, Sabina, RL

J Biol Chem 1998
1429593 Molecular cloning of AMP deaminase isoform L. Sequence and bacterial expression of human AMPD2 cDNA

Bausch-Jurken, MT, Mahnke-Zizelman, DK, Morisaki, T, Sabina, RL

J Biol Chem 1992
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
AMP deaminase activity of AMPD tetramers [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Created