Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)
Stable Identifier
R-HSA-77073
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA Pol II CTD phosphorylation and interaction with CE (Homo sapiens)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Homo sapiens)
Metabolism of RNA (Homo sapiens)
mRNA Capping (Homo sapiens)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
here
to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The capping enzyme interacts with the Spt5 subunit of transcription elongation factor DSIF. This interaction may couple the capping reaction with promoter escape or elongation, thereby acting as a "checkpoint" to assure that capping has occurred before the polymerase proceeds to make the rest of the transcript (Gonatopoulos-Pournatzis et al.2011).
Literature References
PubMed ID
Title
Journal
Year
24354960
Cap-binding complex (CBC)
Gonatopoulos-Pournatzis, T
,
Cowling, VH
Biochem. J.
2014
Participants
Input
p-SUPT5H [nucleoplasm]
(Homo sapiens)
RNA Pol II with phosphorylated CTD: CE complex with activated GT [nucleoplasm]
(Homo sapiens)
RNMT [nucleoplasm]
(Homo sapiens)
Output
CE:Pol II CTD:Spt5 complex [nucleoplasm]
(Homo sapiens)
Participates
as an event of
mRNA Capping (Homo sapiens)
RNA Pol II CTD phosphorylation and interaction with CE (Homo sapiens)
Orthologous Events
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Bos taurus)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Caenorhabditis elegans)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Canis familiaris)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Danio rerio)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Dictyostelium discoideum)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Drosophila melanogaster)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Homo sapiens)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Mus musculus)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Plasmodium falciparum)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Rattus norvegicus)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Saccharomyces cerevisiae)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Schizosaccharomyces pombe)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Sus scrofa)
Authored
Buratowski, S (2003-10-15)
Created
Buratowski, S (2003-10-15)
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text