SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)

Stable Identifier
R-HSA-77073
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The capping enzyme interacts with the Spt5 subunit of transcription elongation factor DSIF. This interaction may couple the capping reaction with promoter escape or elongation, thereby acting as a "checkpoint" to assure that capping has occurred before the polymerase proceeds to make the rest of the transcript (Gonatopoulos-Pournatzis et al.2011).

Literature References
PubMed ID Title Journal Year
24354960 Cap-binding complex (CBC)

Gonatopoulos-Pournatzis, T, Cowling, VH

Biochem. J. 2014
Participants
Participant Of
Orthologous Events
Authored
Created