Reactome | Capping complex formation

Capping complex formation

Stable Identifier

R-HSA-77077

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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The capping enzyme binds the 5'-end of the nascent transcript soon after it is synthesized on the DNA template, and results in the formation of the capping complex along with the C-terminal domain of RNA polymerase II, and Spt5 (Heidemann et al. 2013, Buratowski 2009, Schoenberg and Maquat 2009).

Literature References

PubMed ID	Title	Journal	Year
22982363	Dynamic phosphorylation patterns of RNA polymerase II CTD during transcription Voß, K, Eick, D, Heidemann, M, Hintermair, C	Biochim. Biophys. Acta	2013
19729311	Re-capping the message Maquat, LE, Schoenberg, DR	Trends Biochem. Sci.	2009
19941815	Progression through the RNA polymerase II CTD cycle Buratowski, S	Mol. Cell	2009
24354960	Cap-binding complex (CBC) Gonatopoulos-Pournatzis, T, Cowling, VH	Biochem. J.	2014