Capping complex formation

Stable Identifier
R-HSA-77077
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The capping enzyme binds the 5'-end of the nascent transcript soon after it is synthesized on the DNA template, and results in the formation of the capping complex along with the C-terminal domain of RNA polymerase II, and Spt5 (Heidemann et al. 2013, Buratowski 2009, Schoenberg and Maquat 2009).

Literature References
PubMed ID Title Journal Year
19729311 Re-capping the message

Schoenberg, DR, Maquat, LE

Trends Biochem. Sci. 2009
22982363 Dynamic phosphorylation patterns of RNA polymerase II CTD during transcription

Heidemann, M, Hintermair, C, Voß, K, Eick, D

Biochim. Biophys. Acta 2013
19941815 Progression through the RNA polymerase II CTD cycle

Buratowski, S

Mol. Cell 2009
24354960 Cap-binding complex (CBC)

Gonatopoulos-Pournatzis, T, Cowling, VH

Biochem. J. 2014
Participants
Participant Of
hasEvent
Orthologous Events
Authored