Formation of the CE:GMP intermediate complex

Stable Identifier
R-HSA-77081
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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Formation of the CE:GMP intermediate complex
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A highly conserved lysine within the guanylyltransferase (GT) site of the mRNA capping enzyme attacks the alpha-phosphate of GTP. An enzyme-GMP covalent intermediate is formed.

Literature References
PubMed ID Title Journal Year
9512541 Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme.

Yamada-Okabe, T, Doi, R, Shimmi, O, Arisawa, M, Yamada-Okabe, H

Nucleic Acids Res 1998
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Catalyst Activity

mRNA guanylyltransferase activity of Capping complex (hydrolyzed) [nucleoplasm]

Physical Entity
Capping complex (hydrolyzed) [nucleoplasm] (Homo sapiens)
Activity
mRNA guanylyltransferase activity (GO:0004484)
Orthologous Events
Formation of the CE:GMP intermediate complex (Caenorhabditis elegans)
Formation of the CE:GMP intermediate complex (Canis familiaris)
Formation of the CE:GMP intermediate complex (Danio rerio)
Formation of the CE:GMP intermediate complex (Dictyostelium discoideum)
Formation of the CE:GMP intermediate complex (Drosophila melanogaster)
Formation of the CE:GMP intermediate complex (Gallus gallus)
Formation of the CE:GMP intermediate complex (Mus musculus)
Formation of the CE:GMP intermediate complex (Plasmodium falciparum)
Formation of the CE:GMP intermediate complex (Rattus norvegicus)
Formation of the CE:GMP intermediate complex (Saccharomyces cerevisiae)
Formation of the CE:GMP intermediate complex (Schizosaccharomyces pombe)
Formation of the CE:GMP intermediate complex (Sus scrofa)
Authored
Buratowski, S  (2003-10-15)
Created
Buratowski, S  (2003-10-15)
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