Methylation of GMP-cap by RNA Methyltransferase

Stable Identifier
R-HSA-77090
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In the final step of the capping reaction, the methyltransferase takes a methyl group from S-adenosyl-methionine to the N7 position of the cap guanine. N7G-methyltransferase (MT) mediated reaction can be represented as:
GpppN(pN)n + S-adenosylmethionine (Adomet) ->m7GpppN(pN)n + S-adenosylhomocysteine (Adohcy).

Literature References
PubMed ID Title Journal Year
9790902 Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)-methyltransferase, an mRNA cap methylase.

Tsukamoto, T, Shibagaki, Y, Niikura, Y, Mizumoto, K

Biochem Biophys Res Commun 1998
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
mRNA (guanine-N7-)-methyltransferase activity of Capping complex (with freed 5'- GMP) [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Created