Reactome | HADHA [mitochondrial inner membrane]

HADHA [mitochondrial inner membrane]

Stable Identifier

R-HSA-77264

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Trifunctional enzyme alpha subunit, Trifunctional enzyme alpha subunit, mitochondrial precursor, TP-alpha, 78 kDa gastrin-binding protein, Long-chain enoyl-CoA hydratase , Long chain 3-hydroxyacyl-CoA dehydrogenase

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P40939 HADHA

Gene Names

HADHA, HADH

Chain

transit peptide:1-36, chain:37-763

Reference Genes

BioGPS Gene:3030 HADHA

COSMIC (genes):HADH HADH

COSMIC (genes):HADHA HADHA

CTD Gene:3030 HADHA

dbSNP Gene:3030 HADHA

ENSEMBL:ENSG00000084754 HADHA

HGNC:4801 HADHA

KEGG:hsa:3030 HADHA

Monarch:3030 HADHA

NCBI Gene:3030 HADHA

OMIM:600890 HADHA

UCSC:P40939 HADHA

Reference Transcript

RefSeq:NM_000182.4 HADHA

Other Identifiers

11715522_a_at

11715523_a_at

11754123_s_at

11760555_at

16895471

208629_PM_s_at

208629_s_at

208630_PM_at

208630_at

208631_PM_s_at

208631_s_at

2545093

2545094

2545095

2545096

2545097

2545098

2545099

2545100

2545101

2545102

2545103

2545105

2545107

2545108

2545109

2545112

2545113

2545116

2545119

2545120

2545121

2545122

2545123

2545125

2545126

2545127

2545128

2545129

2545130

2545133

2545134

2545135

2545136

2792499

2792502

3030

3403815

3403816

36952_at

52313_at

8050908

A_24_P242688

A_24_P353964

D16480_at

GE56884

GE61246

GE80899

GO:0000062

GO:0003824

GO:0003857

GO:0003985

GO:0003988

GO:0004300

GO:0005515

GO:0005739

GO:0005743

GO:0006629

GO:0006631

GO:0006635

GO:0008289

GO:0009410

GO:0016491

GO:0016507

GO:0016509

GO:0016616

GO:0016740

GO:0016829

GO:0018812

GO:0032868

GO:0035965

GO:0042645

GO:0043226

GO:0044877

GO:0051287

GO:0070403

HMNXSV003021582

Hs.75860.0.A1_3p_a_at

Hs.75860.0.A3_3p_at

ILMN_1712751

PH_hs_0028970

TC02001665.hg

g595266_3p_a_at

Participates

as a component of

Inferred To

Mtpalpha [mitochondrial inner membrane] (Drosophila melanogaster)

hadhab [mitochondrial inner membrane] (Danio rerio)

HADHA [mitochondrial inner membrane] (Bos taurus)

HADHA [mitochondrial inner membrane] (Canis familiaris)

HADHA [mitochondrial inner membrane] (Gallus gallus)

HADHA [mitochondrial inner membrane] (Sus scrofa)

Hadha [mitochondrial inner membrane] (Mus musculus)

Hadha [mitochondrial inner membrane] (Rattus norvegicus)

ech-1.2 [mitochondrial inner membrane] (Caenorhabditis elegans)

hadha [mitochondrial inner membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_000173.2

ENSEMBL

ENSP00000496185, ENST00000646483, ENST00000380649, ENSP00000370023, ENSG00000084754

OpenTargets

ENSG00000084754

IntEnz

1.1.1.211

GeneCards

HADHA

HPA

ENSG00000084754-HADHA

PRO

P40939

Pharos - Targets

P40939

GlyGen

P40939

Orphanet

HADHA

HMDB Protein

HMDBP00389

PDB

5ZRV, 6DV2, 5ZQZ

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.589	2
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P04233 CD74	13	CD74 [plasma membrane] (R-HSA-2130666) CD74 [lysosomal membrane] (R-HSA-2130320) CD74(1-176) [lysosomal membrane] (R-HSA-2130602) CD74 [endocytic vesicle membrane] (R-HSA-2130460) CD74 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130522) CD74 [transport vesicle membrane] (R-HSA-2130624) CD74 [trans-Golgi network membrane] (R-HSA-2130493) CD74 [Golgi membrane] (R-HSA-2214388) CD74 [ER to Golgi transport vesicle membrane] (R-HSA-2130456) CD74 [lumenal side of endoplasmic reticulum membrane] (R-HSA-1181241) CD74(1-117) [lysosomal membrane] (R-HSA-2130632) CD74(81-104) [lysosomal membrane] (R-HSA-2130446) CD74(81-104) [lysosomal lumen] (R-HSA-2213220)	0.547	2
cardiolipin [ChEBI:28494]	4	cardiolipin [plasma membrane] (R-ALL-9647661) CL [endoplasmic reticulum membrane] (R-ALL-1524081) cardiolipin [mitochondrial outer membrane] (R-ALL-8954419) cardiolipin [mitochondrial inner membrane] (R-ALL-1524072)	0.544	2
UniProt:O15530 PDPK1	3	PDPK1 [plasma membrane] (R-HSA-61459) PDPK1 [cytosol] (R-HSA-202210) p-S241-PDPK1 [cytosol] (R-HSA-9860799)	0.527	3
UniProt:P34741 SDC2	20	HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643) HS(3)-SDC2 [plasma membrane] (R-HSA-2076631) HS(5)-SDC2 [plasma membrane] (R-HSA-2076665) SDC2 [endoplasmic reticulum lumen] (R-HSA-8956741) p-SDC2 [endoplasmic reticulum lumen] (R-HSA-8956945) SDC2 [Golgi lumen] (R-HSA-2054101) XylS-SDC2 [Golgi lumen] (R-HSA-2064109) Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2064132) Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063988) GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063997) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607) Heparan(4)-SDC2 [Golgi lumen] (R-HSA-2076576) Heparan(3)-SDC2 [Golgi lumen] (R-HSA-2076361) Heparan(2)-SDC2 [Golgi lumen] (R-HSA-2076397) Heparan(1)-SDC2 [Golgi lumen] (R-HSA-2076536)	0.527	3
UniProt:Q16288 NTRK3	6	p-5Y-NTRK3 [plasma membrane] (R-HSA-9034718) NTRK3 [plasma membrane] (R-HSA-6798240) NTRK3(496-641) [cytosol] (R-HSA-9603542) NTRK3(496-641) [mitochondrial outer membrane] (R-HSA-9603557) NTRK3(642-839) [cytosol] (R-HSA-9603540) NTRK3(32-495) [plasma membrane] (R-HSA-9603541)	0.527	2
UniProt:Q05513 PRKCZ	5	PRKCZ [cell junction] (R-HSA-2134483) p-T410-PRKCZ [cytosol] (R-HSA-437181) p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) PRKCZ [cytosol] (R-HSA-58218) pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824)	0.527	2
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [cytosol] (R-HSA-5205651) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [autophagosome membrane] (R-HSA-5683641)	0.525	4
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.483	2
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	4

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