Reactome | HADHB [mitochondrial inner membrane]

HADHB [mitochondrial inner membrane]

Stable Identifier

R-HSA-77266

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Trifunctional enzyme beta subunit, Trifunctional enzyme beta subunit, mitochondrial precursor, TP-beta, 3-ketoacyl-CoA thiolase , Acetyl-CoA acyltransferase, Beta-ketothiolase

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P55084 HADHB

Gene Names

HADHB, MSTP029

Chain

transit peptide:1-33, chain:34-474

Reference Genes

BioGPS Gene:3032 HADHB

COSMIC (genes):HADHB HADHB

CTD Gene:3032 HADHB

dbSNP Gene:3032 HADHB

ENSEMBL:ENSG00000138029 HADHB

HGNC:4803 HADHB

KEGG:hsa:3032 HADHB

Monarch:3032 HADHB

NCBI Gene:3032 HADHB

OMIM:143450 HADHB

UCSC:P55084 HADHB

Reference Transcript

Other Identifiers

11725038_s_at

11745163_s_at

11745164_x_at

11747745_a_at

11747746_x_at

16877860

201007_PM_at

201007_at

2473736

2473737

2473738

2473740

2473741

2473742

2473743

2473744

2473745

2473746

2473748

2473749

2473750

2473751

2473754

2473756

2473757

2473758

2473759

2473760

2473763

2473764

2473765

2473766

2473767

2473768

2473769

2473773

2473774

2473775

3032

39741_at

3998182

74819_at

8040639

D16481_at

GE80900

GO:0003723

GO:0003824

GO:0003857

GO:0003985

GO:0003988

GO:0004300

GO:0005515

GO:0005739

GO:0005740

GO:0005741

GO:0005743

GO:0005783

GO:0006629

GO:0006631

GO:0006635

GO:0010467

GO:0016491

GO:0016507

GO:0016740

GO:0016746

GO:0016747

GO:0016829

GO:0042645

GO:0043226

GO:0050633

GO:0071222

GO:0106222

HMNXSV003020155

ILMN_2197846

PH_hs_0029551

TC02000149.hg

g4504326_3p_at

Participates

as a component of

Inferred To

HADHB [mitochondrial inner membrane] (Bos taurus)

HADHB [mitochondrial inner membrane] (Canis familiaris)

HADHB [mitochondrial inner membrane] (Gallus gallus)

HADHB [mitochondrial inner membrane] (Sus scrofa)

Hadhb [mitochondrial inner membrane] (Mus musculus)

Hadhb [mitochondrial inner membrane] (Rattus norvegicus)

Mtpbeta [mitochondrial inner membrane] (Drosophila melanogaster)

hadhb [mitochondrial inner membrane] (Danio rerio)

hadhb [mitochondrial inner membrane] (Xenopus tropicalis)

hadb-1 [mitochondrial inner membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_000174.1, XP_011531105.1, NP_001268442.1, NP_001268441.1

ENSEMBL

ENST00000317799, ENSP00000325136, ENSP00000442665, ENSG00000138029, ENST00000545822

OpenTargets

ENSG00000138029

GeneCards

HADHB

HPA

ENSG00000138029-HADHB

PRO

P55084

Pharos - Targets

P55084

GlyGen

P55084

Orphanet

HADHB

HMDB Protein

HMDBP00048

PDB

5ZRV, 6DV2, 5ZQZ

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.643	3
UniProt:O15530 PDPK1	3	PDPK1 [plasma membrane] (R-HSA-61459) PDPK1 [cytosol] (R-HSA-202210) p-S241-PDPK1 [cytosol] (R-HSA-9860799)	0.527	3
UniProt:P34741 SDC2	20	HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643) HS(3)-SDC2 [plasma membrane] (R-HSA-2076631) HS(5)-SDC2 [plasma membrane] (R-HSA-2076665) SDC2 [endoplasmic reticulum lumen] (R-HSA-8956741) p-SDC2 [endoplasmic reticulum lumen] (R-HSA-8956945) SDC2 [Golgi lumen] (R-HSA-2054101) XylS-SDC2 [Golgi lumen] (R-HSA-2064109) Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2064132) Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063988) GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063997) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607) Heparan(4)-SDC2 [Golgi lumen] (R-HSA-2076576) Heparan(3)-SDC2 [Golgi lumen] (R-HSA-2076361) Heparan(2)-SDC2 [Golgi lumen] (R-HSA-2076397) Heparan(1)-SDC2 [Golgi lumen] (R-HSA-2076536)	0.527	3
UniProt:Q05513 PRKCZ	5	PRKCZ [cell junction] (R-HSA-2134483) p-T410-PRKCZ [cytosol] (R-HSA-437181) p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) PRKCZ [cytosol] (R-HSA-58218) pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	11
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	4

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