Reactome: A Curated Pathway Database

Beta oxidation of palmitoyl-CoA to myristoyl-CoA

Stable Identifier
R-HSA-77305
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

This first pass through the beta-oxidation spiral starts with the saturated fatty acid palmitoyl-CoA and produces myristoyl-CoA. Four enzymatic steps are required, starting with VLCAD CoA dehydrogenase (Very Long Chain) activity, followed by three enzymatic steps, enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and ketoacyl-CoA thiolase activities, all present in the mitochondrial membrane associated trifunctional protein.

Literature References
PubMed ID Title Journal Year
  The Metabolic and Molecular Bases of Inherited Disease, 8th ed   2001
Participants
Participant Of
Orthologous Events