(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H

Stable Identifier
R-HSA-77312
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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At the beginning of this reaction, 1 molecule of 'NAD+', and 1 molecule of '(S)-3-Hydroxybutanoyl-CoA' are present. At the end of this reaction, 1 molecule of 'acetoacetyl-CoA', 1 molecule of 'H+', and 1 molecule of 'NADH' are present.

This reaction takes place in the 'mitochondrial matrix' and is mediated by the '3-hydroxyacyl-CoA dehydrogenase activity' of 'short chain 3-hydroxyacyl-CoA dehydrogenase homodimer'.

Literature References
PubMed ID Title Journal Year
8687463 Human short-chain L-3-hydroxyacyl-CoA dehydrogenase: cloning and characterization of the coding sequence.

Vredendaal, PJ, van den Berg, IE, Malingré, HE, Stroobants, AK, Olde Weghuis, DE, Berger, R

Biochem Biophys Res Commun 1996
10231530 Biochemical characterization and crystal structure determination of human heart short chain L-3-hydroxyacyl-CoA dehydrogenase provide insights into catalytic mechanism.

Barycki, JJ, O'Brien, LK, Bratt, JM, Zhang, R, Sanishvili, R, Strauss, AW, Banaszak, LJ

Biochemistry 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
3-hydroxyacyl-CoA dehydrogenase activity of HADH dimer [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Created