Recognition of AAUAAA sequence by CPSF

Stable Identifier
R-HSA-77589
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Recognition of AAUAAA sequence by CPSF
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Poly(A) polymerase has no specificity for any particular RNA sequence, as well as a very low affinity for the RNA. Under physiological conditions, the activity of poly(A) polymerase depends on two auxiliary factors, both of which bind to specific RNA sequences and recruit the poly(A) polymerase by a direct contact. One of these proteins is the heterotetrameric CPSF, which binds the AAUAAA sequence and is also essential for 3' cleavage.
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Orthologous Events
Recognition of AAUAAA sequence by CPSF (Bos taurus)
Recognition of AAUAAA sequence by CPSF (Caenorhabditis elegans)
Recognition of AAUAAA sequence by CPSF (Canis familiaris)
Recognition of AAUAAA sequence by CPSF (Dictyostelium discoideum)
Recognition of AAUAAA sequence by CPSF (Drosophila melanogaster)
Recognition of AAUAAA sequence by CPSF (Mus musculus)
Recognition of AAUAAA sequence by CPSF (Rattus norvegicus)
Recognition of AAUAAA sequence by CPSF (Saccharomyces cerevisiae)
Recognition of AAUAAA sequence by CPSF (Schizosaccharomyces pombe)
Recognition of AAUAAA sequence by CPSF (Sus scrofa)
Authored
Wahle, E  (2003-06-05)
Created
Wahle, E  (2003-06-05)
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