Reactome | Cleavage of Intronless Pre-mRNA at 3'-end

Cleavage of Intronless Pre-mRNA at 3'-end

Stable Identifier

R-HSA-77592

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

nucleoplasm

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SVG | | PPTX | SBGN

Cleavage of Intronless Pre-mRNA at 3'-end

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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The polypeptide catalyzing the hydrolysis of the phosphodiester bond remains to be identified. Cleavage produces a 3'-OH on the upstream fragment and a 5'-phosphate on the downstream fragment. At some unknown point after cleavage, the downstream fragment, CstF, CF I and CF II are thought to be released, whereas CPSF and poly(A) polymerase remain to carry out polyadenylation.

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