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Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC
Stable Identifier
R-HSA-77594
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
,
nuclear envelope
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Transport of Mature Transcript to Cytoplasm (Homo sapiens)
Transport of Mature mRNAs Derived from Intronless Transcripts (Homo sapiens)
Transport of Mature mRNA Derived from an Intronless Transcript (Homo sapiens)
Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The polyadenylated, capped transcript and TAP dock at the nucleoplasmic side of the NPC. The Cap Binding Complex (CBC) and CPSF complexes are released back into the nucleoplasm (Zhou et al. 2000).
Literature References
PubMed ID
Title
Journal
Year
11014198
The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans
Reed, R
,
Luo, MJ
,
Katahira, J
,
Hurt, E
,
Straesser, K
,
Zhou, Z
Nature
2000
15120988
Nuclear export of mRNA: from the site of transcription to the cytoplasm
Erkmann, JA
,
Kutay, U
Exp. Cell Res.
2004
Participants
Input
ALYREF [nucleoplasm]
(Homo sapiens)
Mature intronless derived mRNA complex [nucleoplasm]
(Homo sapiens)
NXF1 [nucleoplasm]
(Homo sapiens)
Output
Cap Binding Complex (CBC) [nucleoplasm]
(Homo sapiens)
CPSF [nucleoplasm]
(Homo sapiens)
Nucleoplasmic mature intronless derived mRNA:TAP:Aly/Ref complex [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Transport of Mature mRNA Derived from an Intronless Transcript (Homo sapiens)
Event Information
Go Biological Process
mRNA export from nucleus (0006406)
This event is regulated
Requirements
Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]'
Orthologous Events
Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Bos taurus)
Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Canis familiaris)
Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Drosophila melanogaster)
Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Mus musculus)
Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Rattus norvegicus)
Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Schizosaccharomyces pombe)
Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC (Sus scrofa)
Authored
Gillespie, ME (2005-01-27)
Created
Wahle, E (2003-06-05)
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