Deamination at C6 position of adenosine in Editosome (ADAR1)

Stable Identifier
R-HSA-77614
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Deamination at C6 position of adenosine in Editosome (ADAR1)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
At the beginning of this reaction, 1 molecule of 'Editosome (ADAR1) complex', and 1 molecule of 'H2O' are present. At the end of this reaction, 1 molecule of 'A to I edited RNA:Editosome (ADAR1) complex', and 1 molecule of 'NH3' are present.

This reaction takes place in the 'nucleus' and is mediated by the 'double-stranded RNA adenosine deaminase activity' of 'ADAR1 homodimer ' (Zheng et al.2017).
Literature References
PubMed ID Title Journal Year
28132026 DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA

Zheng, Y, Beal, PA, Lorenzo, C

Nucleic Acids Res. 2017
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Catalyst Activity

double-stranded RNA adenosine deaminase activity of ADAR1 homodimer [nucleoplasm]

Physical Entity
ADAR1 homodimer [nucleoplasm] (Homo sapiens)
Activity
double-stranded RNA adenosine deaminase activity (GO:0003726)
Orthologous Events
Deamination at C6 position of adenosine in Editosome (ADAR1) (Bos taurus)
Deamination at C6 position of adenosine in Editosome (ADAR1) (Canis familiaris)
Deamination at C6 position of adenosine in Editosome (ADAR1) (Gallus gallus)
Deamination at C6 position of adenosine in Editosome (ADAR1) (Mus musculus)
Deamination at C6 position of adenosine in Editosome (ADAR1) (Rattus norvegicus)
Deamination at C6 position of adenosine in Editosome (ADAR1) (Sus scrofa)
Created
Carmichael, GG  (2003-12-05)
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