Transport of fatty acids

Stable Identifier
R-HSA-804914
Type
Pathway
Species
Homo sapiens
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Long chain fatty acids (LCFAs) are involved in many cellular functions. They can be used as an important source of energy by skeletal muscle and heart tissues. Also, they are used in the production of hormones which can regulate inflammation, blood pressure, the clotting process, blood lipid levels and the immune response. Fatty acid transporter proteins (FATPs) are a family of proteins which mediate fatty acid uptake into cells when overexpressed. FATPs also possess enzymatic activity, the details of which are captured elsewhere. There are 6 human genes of the SLC27A family which encode for FATP1-6 (Stahl A, 2004; Gimeno RE, 2007). To date, only FATP1, 4 and 6 have demonstrable transporter function. Fatty acids with carbon chain lengths of more than 10 are the most likely substrates for these transporters.

Literature References
PubMed ID Title Journal Year
12856180 A current review of fatty acid transport proteins (SLC27)

Stahl, A

Pflugers Arch 2004
17495600 Fatty acid transport proteins

Gimeno, RE

Curr Opin Lipidol 2007
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