Glucagon:GCGR mediates GTP-GDP exchange

Stable Identifier
R-HSA-825631
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The G(s)alpha G-beta G-gamma complex bound to glucagon, in the plasma membrane, releases a molecule of bound GDP, binds a molecule of GTP, and dissociates to yield a G(s)alpha:GTP complex and a G-beta:G-gamma dimer (Siu et al. 2013).

Literature References
PubMed ID Title Journal Year
23863937 Structure of the human glucagon class B G-protein-coupled receptor

Siu, FY, He, M, de Graaf, C, Han, GW, Yang, D, Zhang, Z, Zhou, C, Xu, Q, Wacker, D, Joseph, JS, Liu, W, Lau, J, Cherezov, V, Katritch, V, Wang, MW, Stevens, RC

Nature 2013
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of GCGR:GCG(53-81) [plasma membrane]
Physical Entity
Activity
Authored
Reviewed
Created