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FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8
Stable Identifier
R-HSA-83586
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
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Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
FasL/ CD95L signaling (Homo sapiens)
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Caspase-8 precursor (Pro-Caspase-8, also known as MACH) binds the complex of FADD and FASL:FAS receptor trimer (Boldin et al. 1996).
Literature References
PubMed ID
Title
Journal
Year
8681376
Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
Wallach, D
,
Goncharov, TM
,
Boldin, MP
,
Goltsev, YV
Cell
1996
Participants
Input
CASP8(1-479) [cytosol]
(Homo sapiens)
FASL:FAS Receptor Trimer:FADD [plasma membrane]
(Homo sapiens)
Output
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane]
(Homo sapiens)
Participates
as an event of
FasL/ CD95L signaling (Homo sapiens)
Orthologous Events
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Bos taurus)
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Gallus gallus)
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Mus musculus)
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Rattus norvegicus)
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Sus scrofa)
Authored
Gillespie, ME (2004-08-25)
Reviewed
Salvesen, GS (2013-05-22)
Pop, C (2013-05-22)
Created
Tschopp, J (2004-01-28)
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