Reactome | POLR2L [nucleoplasm]

POLR2L [nucleoplasm]

Stable Identifier

R-HSA-83715

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

HsRPABC5, DNA-directed RNA polymerase II 7.6 kDa polypeptide (EC 2.7.7.6) (RPB10) (RPB7.6), DNA-directed RNA polymerase II 7.6 kDa polypeptide , RPB10, RPB7.6, RPABC5

Locations in the PathwayBrowser for interactor UniProt:O95402 MED26

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External Reference Information

External Reference

UniProt:P62875 POLR2L

Gene Names

POLR2L

Chain

chain:1-67

Reference Genes

BioGPS Gene:5441 POLR2L

COSMIC (genes):POLR2L POLR2L

CTD Gene:5441 POLR2L

dbSNP Gene:5441 POLR2L

ENSEMBL:ENSG00000177700 POLR2L

HGNC:9199 POLR2L

KEGG Gene (Homo sapiens):5441 POLR2L

Monarch:5441 POLR2L

NCBI Gene:5441 POLR2L

OMIM:601189 POLR2L

UCSC:P62875 POLR2L

Reference Transcript

RefSeq:NM_021128.4 POLR2L

Other Identifiers

0001090253

11716442_a_at

11753875_a_at

11753876_x_at

16734154

202586_at

211730_s_at

3358494

3358495

3358498

3358499

3358500

35841_at

503_at

5441

78238_at

7945573

A_23_P33015

GE79031

GO:0000398

GO:0003674

GO:0003677

GO:0003899

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005665

GO:0005666

GO:0005730

GO:0005736

GO:0005737

GO:0005829

GO:0006259

GO:0006283

GO:0006351

GO:0006356

GO:0006360

GO:0006361

GO:0006362

GO:0006363

GO:0006366

GO:0006367

GO:0006368

GO:0006370

GO:0006397

GO:0006950

GO:0007165

GO:0008150

GO:0008270

GO:0008543

GO:0009058

GO:0016070

GO:0016779

GO:0032481

GO:0032991

GO:0034641

GO:0035019

GO:0042795

GO:0042797

GO:0043167

GO:0043226

GO:0044403

GO:0045815

GO:0046872

GO:0050434

GO:0060964

Hs.71618.0.S2_3p_at

ILMN_1670037

TC11001251.hg

U37690_at

g13543491_3p_s_at

Participant Of

hasComponent

input

Assembly of RNA Polymerase I Holoenzyme (human)

Other forms of this molecule

POLR2L [cytosol]

Inferred To

polr2l [nucleoplasm] (Danio rerio)

polr2l [nucleoplasm] (Dictyostelium discoideum)

Homologues of POLR2L [nucleoplasm] (Rattus norvegicus)

POLR2L [nucleoplasm] (Bos taurus)

POLR2L [nucleoplasm] (Gallus gallus)

POLR2L [nucleoplasm] (Plasmodium falciparum)

POLR2L [nucleoplasm] (Rattus norvegicus)

POLR2L [nucleoplasm] (Sus scrofa)

Rpb10 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of POLR2L [nucleoplasm] (Canis familiaris)

Polr2l [nucleoplasm] (Mus musculus)

rpb10 [nucleoplasm] (Schizosaccharomyces pombe)

polr2l.1 [nucleoplasm] (Xenopus tropicalis)

RPB10 [nucleoplasm] (Saccharomyces cerevisiae)

rpb-10 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_066951.1

Target Pathogen

5b354852be737e166372ec02

OpenTargets

ENSG00000177700

HPA

ENSG00000177700-POLR2L

GeneCards

P62875

Ensembl

ENSP00000324124, ENSP00000432807, ENST00000322028, ENSG00000177700, ENST00000534030

PRO

P62875

HMDB Protein

HMDBP11915

PDB

5IYD, 5IYB, 5IY6, 5IY8, 6O9L, 5IY9, 5IY7, 5IYA, 6DRD, 5IYC

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O15514 POLR2D	1	POLR2D [nucleoplasm] (R-HSA-63508)	0.659	3
UniProt:P19388 POLR2E	2	POLR2E [cytosol] (R-HSA-1964438) POLR2E [nucleoplasm] (R-HSA-83713)	0.648	4
UniProt:Q96R06 SPAG5			0.556	3
UniProt:Q96JM7 LMBL3			0.556	3
UniProt:P38432 COIL			0.556	3
UniProt:Q04864 REL	2	REL [nucleoplasm] (R-HSA-1168585) REL [cytosol] (R-HSA-1168579)	0.556	3
UniProt:Q9NTX9 F217B			0.556	3
UniProt:Q04864-2 REL			0.556	3
UniProt:Q9NVV9 THAP1			0.556	3
UniProt:Q15645 PCH2			0.556	3
UniProt:Q9BWH6 RPAP1			0.556	3
UniProt:Q13625-3 TP53BP2			0.556	3
UniProt:P60900 PSMA6	2	PSMA6 [cytosol] (R-HSA-68734) PSMA6 [nucleoplasm] (R-HSA-174314)	0.556	3
UniProt:Q8IXK0 PHC2	1	PHC2 [nucleoplasm] (R-HSA-389112)	0.556	3
UniProt:Q8N9N5 BANP	1	BANP [nucleoplasm] (R-HSA-3221973)	0.556	3
UniProt:Q96RE7 NACC1			0.556	3
UniProt:O43829 ZBT14			0.556	3
UniProt:O95994 AGR2			0.556	3
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.527	3
UniProt:A0JLT2 MED19	1	MED19 [nucleoplasm] (R-HSA-556819)	0.527	2

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