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TBP [nucleoplasm]
Stable Identifier
R-HSA-83718
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
TATA box binding protein (Transcription initiation factor TFIID) (TATA-box factor) (TATA sequence-binding protein) (TBP), TATA-box binding protein, TATA-box factor, TATA binding factor, TATA sequence-binding protein, Transcription initiation factor TFIID TBP subunit
Locations in the PathwayBrowser for interactor UniProt:P03070
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase I Transcription (Homo sapiens)
RNA Polymerase I Promoter Clearance (Homo sapiens)
RNA Polymerase I Transcription Initiation (Homo sapiens)
Formation of SL1 (Homo sapiens)
TBP [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA polymerase II transcribes snRNA genes (Homo sapiens)
General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Homo sapiens)
TBP [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Estrogen-dependent gene expression (Homo sapiens)
TBP and TFIIA bind TATA box on ESR1:estrogen bound TFF1 gene promoter (Homo sapiens)
TBP [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20226 TBP
Gene Names
TBP, GTF2D1, TF2D, TFIID
Chain
chain:1-339
Reference Genes
BioGPS Gene:6908 TBP
COSMIC (genes):TBP TBP
CTD Gene:6908 TBP
dbSNP Gene:6908 TBP
ENSEMBL:ENSG00000112592 TBP
ENSEMBL_homo_sapiens_GENE:ENSG00000112592.15 TBP
HGNC:11588 TBP
KEGG Gene (Homo sapiens):6908 TBP
Monarch:6908 TBP
NCBI Gene:6908 TBP
OMIM:600075 TBP
UCSC:P20226 TBP
Reference Transcript
RefSeq:NM_001172085.1 TBP
RefSeq:NM_003194.4 TBP
Other Identifiers
11735454_s_at
11749863_a_at
17014929
203135_PM_at
203135_at
2937985
2937990
2937991
2937992
2937993
2937994
2937995
2937997
2937998
2938002
2938003
2938005
2938007
2938008
2938009
41441_at
6908
8123507
A_23_P19313
GE57977
GO:0000785
GO:0000791
GO:0000976
GO:0000978
GO:0000979
GO:0000995
GO:0001046
GO:0001091
GO:0001093
GO:0001673
GO:0001674
GO:0001939
GO:0001940
GO:0003677
GO:0005515
GO:0005634
GO:0005654
GO:0005668
GO:0005669
GO:0005672
GO:0005694
GO:0005730
GO:0005737
GO:0006351
GO:0006352
GO:0006355
GO:0006366
GO:0006367
GO:0006383
GO:0007283
GO:0016071
GO:0016251
GO:0017162
GO:0019899
GO:0022414
GO:0032991
GO:0042789
GO:0043226
GO:0045120
GO:0045893
GO:0051123
GO:0060261
GO:0061629
GO:0065003
GO:0140223
GO:0140297
HMNXSV003005594
ILMN_1697117
PH_hs_0000144
TC06001201.hg
TC06003242.hg
X54993_s_at
g4507378_3p_at
Participates
as a component of
TBP:TFIIA:DDX5:ESR1:estrogen:TFF1 gene:FOXA1:GATA3 [nucleoplasm] (Homo sapiens)
TFIIIB-Type 3 Promoter Selective Complex [nucleoplasm] (Homo sapiens)
TFIIIB-Type 1 and 2 Promoter Selective Complex [nucleoplasm] (Homo sapiens)
SL1 [nucleoplasm] (Homo sapiens)
Acetylated SL1 [nucleoplasm] (Homo sapiens)
RNA polymerase II (unphosphorylated):Initiation factors [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
TFIID [nucleoplasm] (Homo sapiens)
as an input of
TBP and TFIIA bind TATA box on ESR1:estrogen bound TFF1 gene promoter (Homo sapiens)
Formation of SL1 (Homo sapiens)
General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Homo sapiens)
Inferred To
Ghost homologue of TBP [nucleoplasm]
(Sus scrofa)
SPT15 [nucleoplasm]
(Saccharomyces cerevisiae)
tbp1 [nucleoplasm]
(Schizosaccharomyces pombe)
tbp [nucleoplasm]
(Danio rerio)
tbp [nucleoplasm]
(Xenopus tropicalis)
Trf [nucleoplasm]
(Drosophila melanogaster)
Homologues of TBP [nucleoplasm]
(Drosophila melanogaster)
TBP [nucleoplasm]
(Bos taurus)
TBP [nucleoplasm]
(Canis familiaris)
TBP [nucleoplasm]
(Gallus gallus)
tbpA [nucleoplasm]
(Dictyostelium discoideum)
Tbp [nucleoplasm]
(Drosophila melanogaster)
Tbp [nucleoplasm]
(Mus musculus)
Tbp [nucleoplasm]
(Rattus norvegicus)
tbp-1 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001165556.1
,
NP_003185.1
OpenTargets
ENSG00000112592
HPA
ENSG00000112592-TBP
GeneCards
P20226
Ensembl
ENSG00000112592
,
ENSP00000230354
,
ENST00000230354
,
ENSP00000442132
,
ENST00000392092
,
ENSP00000375942
,
ENST00000540980
PRO
P20226
Pharos - Targets
P20226
Orphanet
15583
PDB
5IY9
,
6MZM
,
1TGH
,
5IY7
,
5IY8
,
7NVZ
,
7ENC
,
7ENA
,
7NW0
,
1C9B
,
7NVY
,
7NVU
,
5IY6
,
7EGA
,
8ITY
,
7ZWD
,
4ROE
,
4ROD
,
7EGJ
,
7ZWC
,
7NVT
,
5IYB
,
7ZXE
,
5IYA
,
7EGI
,
7EG9
,
4ROC
,
7EG7
,
6O9L
,
7EGF
,
8GXQ
,
7EGE
,
7ZX8
,
6MZL
,
7ZX7
,
7EGD
,
7EGC
,
6MZD
,
8IUH
,
8BVW
,
7EGB
,
8IUE
,
5IYC
,
5IYD
,
7NVS
,
7LBM
,
7NVR
,
8BZ1
,
5N9G
,
7EG8
,
8BYQ
,
7EDX
,
5FUR
,
1JFI
,
1CDW
,
1NVP
,
8GXS
Interactors (30)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P21675 TAF1
1
TAF1 [nucleoplasm]
(R-HSA-65539)
0.86
10
UniProt:P03070 LT
0.815
8
UniProt:Q12962 TAF10
1
TAF10 [nucleoplasm]
(R-HSA-65551)
0.725
5
UniProt:Q15542 TAF5
1
TAF5 [nucleoplasm]
(R-HSA-65543)
0.725
4
UniProt:Q53T94 TAF1B
2
TAF1B [nucleoplasm]
(R-HSA-73691)
Ac-TAF1B [nucleoplasm]
(R-HSA-5138530)
0.688
4
UniProt:Q16514 TAF12
1
TAF12 [nucleoplasm]
(R-HSA-65555)
0.669
3
UniProt:Q15572 TAF1C
1
TAF1C [nucleoplasm]
(R-HSA-73687)
0.656
3
UniProt:O00268 TAF4
1
TAF4 [nucleoplasm]
(R-HSA-65541)
0.643
3
UniProt:Q01105 SET
1
SET [nucleoplasm]
(R-HSA-451201)
0.632
4
UniProt:Q16236 NFE2L2
13
p-S,T,S558-NFE2L2 [nucleoplasm]
(R-HSA-9795736)
p-S40, S344, S347- NFE2L2 [nucleoplasm]
(R-HSA-9762050)
p-S344, S347,T-NFE2L2 [nucleoplasm]
(R-HSA-9762048)
ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]
(R-HSA-9762058)
ub-p-S335, S338,T-NFE2L2 [nucleoplasm]
(R-HSA-9762055)
ub-NFE2L2 [cytosol]
(R-HSA-9758077)
p-S40-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760018)
p-S,T-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760033)
NFE2L2 [cytosol]
(R-HSA-201566)
p-S,T-NFE2L2 [cytosol]
(R-HSA-8932311)
p-S40-NFE2L2 [cytosol]
(R-HSA-8932290)
p-S,T-NFE2L2 [nucleoplasm]
(R-HSA-9715110)
p-S40-NFE2L2 [nucleoplasm]
(R-HSA-9715109)
0.625
5
UniProt:P52657 GTF2A2
1
GTF2A2 [nucleoplasm]
(R-HSA-65533)
0.623
2
UniProt:Q05906 ICP27
0.611
4
UniProt:P03120 VE2
0.592
2
UniProt:Q00403 GTF2B
1
GTF2B [nucleoplasm]
(R-HSA-65888)
0.589
2
UniProt:P52655 GTF2A1
2
GTF2A1(275-376) [nucleoplasm]
(R-HSA-109768)
GTF2A1(1-274) [nucleoplasm]
(R-HSA-109767)
0.564
2
UniProt:Q15573 TAF1A
1
TAF1A [nucleoplasm]
(R-HSA-73689)
0.564
2
UniProt:Q9H5J8 TAF1D
1
TAF1D [nucleoplasm]
(R-HSA-5138533)
0.564
2
UniProt:L8B1Q7 L8B1Q7
0.558
3
UniProt:Q00535 CDK5
4
CDK5 [nucleoplasm]
(R-HSA-8863586)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
CDK5 [cytosol]
(R-HSA-180064)
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q92994 BRF1
1
BRF1 [nucleoplasm]
(R-HSA-65894)
0.547
2
UniProt:P87662 P87662
0.544
2
UniProt:Q6JGG5 Q6JGG5
0.544
3
UniProt:P35226 BMI1
3
BMI1 [nucleoplasm]
(R-HSA-389121)
p-S-BMI1 [nucleoplasm]
(R-HSA-3229116)
monoSUMO1-K88-BMI1 [nucleoplasm]
(R-HSA-4551729)
0.527
2
UniProt:P20265 POU3F2
1
POU3F2 [nucleoplasm]
(R-HSA-9613754)
0.527
2
UniProt:P49848 TAF6
1
TAF6 [nucleoplasm]
(R-HSA-65545)
0.527
2
UniProt:Q15545 TAF7
1
TAF7 [nucleoplasm]
(R-HSA-212347)
0.527
2
UniProt:P18111 CDX1
0.524
5
UniProt:O60869-1 EDF1
0.499
2
UniProt:Q5HZG4
1
Taf3 [nucleoplasm]
(R-MMU-212446)
0.462
2
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