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PRPF8 [nucleoplasm]
Stable Identifier
R-HSA-83810
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
hPrp8
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Disassembly of the Intron Lariat Spliceosome (new) (Homo sapiens)
Intron Lariat Spliceosome (ILS) [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
PRPF8 [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
PRPF8 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B complex (Homo sapiens)
Spliceosomal B complex [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
PRPF8 [nucleoplasm] (Homo sapiens)
U5 snRNP [nucleoplasm] (Homo sapiens)
PRPF8 [nucleoplasm] (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
U4:U5:U6 tri-snRNP complex [nucleoplasm] (Homo sapiens)
U5 snRNP [nucleoplasm] (Homo sapiens)
PRPF8 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B* complex (Homo sapiens)
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
PRPF8 [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
PRPF8 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal Bact complex (Homo sapiens)
Spliceosomal B complex [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
PRPF8 [nucleoplasm] (Homo sapiens)
U5 snRNP [nucleoplasm] (Homo sapiens)
PRPF8 [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
PRPF8 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal C* complex (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
PRPF8 [nucleoplasm] (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
PRPF8 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
PRPF8 [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
PRPF8 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal Pre-B complex (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
U4:U5:U6 tri-snRNP complex [nucleoplasm] (Homo sapiens)
U5 snRNP [nucleoplasm] (Homo sapiens)
PRPF8 [nucleoplasm] (Homo sapiens)
U4:U5:U6 tri-snRNP complex [nucleoplasm] (Homo sapiens)
U5 snRNP [nucleoplasm] (Homo sapiens)
PRPF8 [nucleoplasm] (Homo sapiens)
Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
Intron Lariat Spliceosome (ILS) [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
PRPF8 [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
PRPF8 [nucleoplasm] (Homo sapiens)
mRNA Splicing - Minor Pathway (Homo sapiens)
ATAC spliceosome mediated 3' splice site cleavage, exon ligation (Homo sapiens)
ATAC C Complex with lariat containing 5'-end cleaved mRNA [nucleoplasm] (Homo sapiens)
U5 snRNP [nucleoplasm] (Homo sapiens)
PRPF8 [nucleoplasm] (Homo sapiens)
U5 snRNP [nucleoplasm] (Homo sapiens)
PRPF8 [nucleoplasm] (Homo sapiens)
ATAC spliceosome mediated Lariat formation,5' splice site cleavage (Homo sapiens)
ATAC C Complex [nucleoplasm] (Homo sapiens)
U5 snRNP [nucleoplasm] (Homo sapiens)
PRPF8 [nucleoplasm] (Homo sapiens)
ATAC C Complex with lariat containing 5'-end cleaved mRNA [nucleoplasm] (Homo sapiens)
U5 snRNP [nucleoplasm] (Homo sapiens)
PRPF8 [nucleoplasm] (Homo sapiens)
Formation of AT-AC B Complex (Homo sapiens)
ATAC B Complex [nucleoplasm] (Homo sapiens)
U4 ATAC:U5:U6 ATAC Complex [nucleoplasm] (Homo sapiens)
U5 snRNP [nucleoplasm] (Homo sapiens)
PRPF8 [nucleoplasm] (Homo sapiens)
U4 ATAC:U5:U6 ATAC Complex [nucleoplasm] (Homo sapiens)
U5 snRNP [nucleoplasm] (Homo sapiens)
PRPF8 [nucleoplasm] (Homo sapiens)
Formation of AT-AC C complex (Homo sapiens)
ATAC B Complex [nucleoplasm] (Homo sapiens)
U4 ATAC:U5:U6 ATAC Complex [nucleoplasm] (Homo sapiens)
U5 snRNP [nucleoplasm] (Homo sapiens)
PRPF8 [nucleoplasm] (Homo sapiens)
ATAC C Complex [nucleoplasm] (Homo sapiens)
U5 snRNP [nucleoplasm] (Homo sapiens)
PRPF8 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6P2Q9 PRPF8
Gene Names
PRPF8, PRPC8
Chain
initiator methionine:1, chain:2-2335
Reference Genes
BioGPS Gene:10594 PRPF8
COSMIC (genes):PRPF8 PRPF8
CTD Gene:10594 PRPF8
dbSNP Gene:10594 PRPF8
ENSEMBL:ENSG00000174231 PRPF8
ENSEMBL:ENSG00000174231.18 PRPF8
ENSEMBL:ENSG00000274442.2 PRPF8
HGNC:17340 PRPF8
KEGG Gene (Homo sapiens):10594 PRPF8
Monarch:10594 PRPF8
NCBI Gene:10594 PRPF8
OMIM:607300 PRPF8
UCSC:Q6P2Q9 PRPF8
Reference Transcript
RefSeq:NM_006445.3 PRPF8
Other Identifiers
10594
11715531_at
16839473
18671491
18671492
18671493
18671494
18671495
18671496
18671497
18671498
18671499
18671500
18671501
18671502
18671503
18671504
18671505
18671506
18671507
18671508
18671509
18671510
18671511
18671512
18671513
18671514
18671515
18671516
18671517
18671518
18671519
18671520
18671521
18671522
18671523
18671524
18671525
18671526
18671527
18671528
200000_PM_s_at
200000_s_at
35753_at
3740480
3740481
3740482
3740483
3740484
3740485
3740486
3740487
3740488
3740492
3740494
3740496
3740497
3740498
3740499
3740500
3740501
3740503
3740504
3740506
3740507
3740508
3740509
3740510
3740511
3740512
3740514
3740516
3740517
3740518
3740519
3740520
3740521
3740522
3740523
3740524
3740525
3740526
3740527
3740528
3740530
3740531
3740532
3740533
3740534
3740535
3740537
3740538
3740539
3740540
7892542
7892764
7892884
7892890
7893032
7893153
7893261
7893271
7893364
7893494
7893534
7893551
7893681
7893910
7894421
7894431
7894489
7894498
7894548
7894555
7894662
7895052
7895077
7895162
7895192
7895289
7895290
7895340
7895356
7895414
7895515
7895525
7895676
7895758
7895767
7895853
7895890
7895981
7896156
7896210
7896456
7896474
7896508
7896594
7896647
7896673
7896685
8011141
A_23_P38219
A_32_P402521
GE62898
GO:0000244
GO:0000375
GO:0000398
GO:0003723
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005681
GO:0005682
GO:0006397
GO:0008233
GO:0008237
GO:0008380
GO:0016020
GO:0016071
GO:0016607
GO:0016787
GO:0017070
GO:0030532
GO:0030619
GO:0030620
GO:0030623
GO:0043226
GO:0046540
GO:0065003
GO:0070530
GO:0071005
GO:0071006
GO:0071007
GO:0071013
GO:0071222
GO:0071356
GO:0097157
GO:0140096
GO:1990904
HMNXSV003028061
ILMN_1738677
PH_hs_0010731
TC17000981.hg
g5453983_3p_s_at
Participates
as a component of
U5 snRNP [nucleoplasm] (Homo sapiens)
U5 snRNP (no DDX23,PRPF6,TXNL4A) [nucleoplasm] (Homo sapiens)
Inferred To
PRPF8 [nucleoplasm]
(Bos taurus)
PRPF8 [nucleoplasm]
(Canis familiaris)
PRPF8 [nucleoplasm]
(Danio rerio)
PRPF8 [nucleoplasm]
(Gallus gallus)
PRPF8 [nucleoplasm]
(Plasmodium falciparum)
PRPF8 [nucleoplasm]
(Sus scrofa)
prpf8 [nucleoplasm]
(Dictyostelium discoideum)
prpf8 [nucleoplasm]
(Xenopus tropicalis)
prp-8 [nucleoplasm]
(Caenorhabditis elegans)
Prpf8 [nucleoplasm]
(Mus musculus)
Prpf8 [nucleoplasm]
(Rattus norvegicus)
spp42 [nucleoplasm]
(Schizosaccharomyces pombe)
Prp8 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_006436.3
OpenTargets
ENSG00000174231
HPA
ENSG00000174231-PRPF8
GeneCards
Q6P2Q9
Ensembl
ENST00000634039
,
ENST00000614672
,
ENSP00000488611
,
ENSG00000174231
,
ENSP00000304350
,
ENSG00000274442
,
ENST00000304992
,
ENST00000572621
,
ENSP00000479194
,
ENSP00000460348
PRO
Q6P2Q9
Pharos - Targets
Q6P2Q9
Orphanet
15151
PDB
7ABF
,
6ZYM
,
7W5A
,
7W5B
,
7ABG
,
4JKD
,
7PJH
,
4JK7
,
8BCG
,
7W59
,
5Z58
,
5XJC
,
8BCE
,
8BCF
,
6QX9
,
6ICZ
,
6ID1
,
8BCD
,
5MQF
,
3E9L
,
7AAV
,
7A5P
,
8BCC
,
6ID0
,
4JK9
,
8BCB
,
4JKA
,
6FF7
,
4KIT
,
7DVQ
,
4JK8
,
6FF4
,
6AHD
,
8BCA
,
6QW6
,
6S9I
,
3JCR
,
3ENB
,
8BC9
,
4JKE
,
4JKG
,
8BC8
,
4JKF
,
6AH0
,
7OS2
,
4JKB
,
6S8Q
,
5Z57
,
4JKC
,
3LRU
,
7BDL
,
5YZG
,
5O9Z
,
7PX3
,
7BDJ
,
6QDV
,
7BDK
,
5Z56
,
7BDI
,
4JKH
,
7ABI
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O94906 PRPF6
1
PRPF6 [nucleoplasm]
(R-HSA-71881)
0.706
5
UniProt:Q9CSN1 Snw1
1
Snw1 [nucleoplasm]
(R-MMU-2065315)
0.564
2
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.527
2
UniProt:Q92917 GPKOW
1
GPKOW [nucleoplasm]
(R-HSA-8850839)
0.508
2
UniProt:O95391 SLU7
1
hSLU7 [nucleoplasm]
(R-HSA-72073)
0.508
2
UniProt:Q9UJV9 DDX41
4
DDX41 [nucleoplasm]
(R-HSA-9769601)
DDX41 [cytosol]
(R-HSA-3134807)
K48polyUb-DDX41 [cytosol]
(R-HSA-3134942)
K48polyUb-DDX41 [cytosol]
(R-HSA-3134941)
0.462
3
UniProt:P11387 TOP1
2
monoSUMO1-K117-TOP1 [nucleoplasm]
(R-HSA-4641364)
TOP1 [nucleoplasm]
(R-HSA-4641363)
0.462
2
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