Reactome | Phosphorylated TAK1 dissociates from the TLR3 receptor complex

Phosphorylated TAK1 dissociates from the TLR3 receptor complex

Stable Identifier

R-HSA-847070

Type

Reaction [dissociation]

Species

Homo sapiens

Related Species

Influenza A virus, Rotavirus, Hepatitis B virus, Hepatitis C Virus, Human herpesvirus 1

Compartment

endosome membrane, cytosol

ReviewStatus

5/5

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Phosphorylated TAK1 dissociates from the TLR3 receptor complex

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Phosphorylated TAK1 complexed with TRAF6-TAB1-TAB2/TAB3 leaves the activated TLR4 complex and translocates to the cytosol

Literature References

PubMed ID	Title	Journal	Year
12609980	Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR Jiang, Z, Nie, H, Li, X, Williams, BR, Zamanian-Daryoush, M, Silva, AM	J Biol Chem	2003
12242293	Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol Jiang, Z, Ninomiya-Tsuji, J, Li, X, Matsumoto, K, Qian, Y	Mol Cell Biol	2002

Participants

Input

viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:TAB2,TAB3:free polyUb: p-TAK1 [endosome membrane] (Homo sapiens)

Output

Participates

as an event of

TICAM1,TRAF6-dependent induction of TAK1 complex (Homo sapiens)

Orthologous Events

Activated chicken TAK1 dissociates from the activated TLR3 complex (Gallus gallus)

Authored

Shamovsky, V (2010-05-21)

Reviewed

Fitzgerald, KA (2012-11-13)

Gillespie, ME (2010-05-28)

Created

Shamovsky, V (2010-05-29)

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