Reactome: A Curated Pathway Database

Gastrin binds to CCK-B receptor

Stable Identifier
R-HSA-870269
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Gastrin receptors (gastric cholecystokinin B receptor, CCK-BR) mediate acid secretion from parietal cells, release of histamine from enterochromaffin-like (ECL) cells and contraction of smooth muscle (Ito et al. 1993).The hormone gastrin is the central regulator of gastric acid secretion and in addition, plays a prominent role in regulation of growth and differentiation of gastric and colonic mucosa.

Literature References
Participants
Participant Of
Orthologous Events