USP9X (FAM) deubiquitinates SMAD4

Stable Identifier
R-HSA-870437
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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USP9X (FAM) deubiquitinates SMAD4, thereby opposing the negative regulatory activity of TRIM33 (Ectodermin) (Dupont et al. 2009).

Literature References
PubMed ID Title Journal Year
19135894 FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination

Dupont, S, Mamidi, A, Cordenonsi, M, Montagner, M, Zacchigna, L, Adorno, M, Martello, G, Stinchfield, MJ, Soligo, S, Morsut, L, Inui, M, Moro, S, Modena, N, Argenton, F, Newfeld, SJ, Piccolo, S

Cell 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of Ub-SMAD4:USP9X [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created