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p-Y457-IFNGR1 [plasma membrane]
Stable Identifier
R-HSA-873798
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p-IFNGR1, phospho-IFNGR1, p-IFNGR1 (Y457)
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Interferon gamma signaling (Homo sapiens)
Binding of STAT1 to p-IFNGR1 (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:p-JAK1 [plasma membrane] (Homo sapiens)
p-Y457-IFNGR1 [plasma membrane] (Homo sapiens)
STAT1 bound to p-IFNGR1 [plasma membrane] (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:p-JAK1 [plasma membrane] (Homo sapiens)
p-Y457-IFNGR1 [plasma membrane] (Homo sapiens)
IFNG signaling activates MAPKs (Homo sapiens)
Activated JAK1 binds RAF1 (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane] (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:p-JAK1 [plasma membrane] (Homo sapiens)
p-Y457-IFNGR1 [plasma membrane] (Homo sapiens)
JAK1-activated RAF1 phosphorylates MAPKs (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:p-Y-RAF1 [plasma membrane] (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:p-JAK1 [plasma membrane] (Homo sapiens)
p-Y457-IFNGR1 [plasma membrane] (Homo sapiens)
JAK1-mediated phosphorylation of RAF1 (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1 [plasma membrane] (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:p-JAK1 [plasma membrane] (Homo sapiens)
p-Y457-IFNGR1 [plasma membrane] (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:p-Y-RAF1 [plasma membrane] (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:p-JAK1 [plasma membrane] (Homo sapiens)
p-Y457-IFNGR1 [plasma membrane] (Homo sapiens)
Phosphorylation of IFNGR1 by JAK kinases (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:p-JAK1 [plasma membrane] (Homo sapiens)
p-Y457-IFNGR1 [plasma membrane] (Homo sapiens)
Phosphorylation of STAT1 at Ser727 (Homo sapiens)
p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:p-JAK1 [plasma membrane] (Homo sapiens)
p-Y457-IFNGR1 [plasma membrane] (Homo sapiens)
p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:p-JAK1 [plasma membrane] (Homo sapiens)
p-Y457-IFNGR1 [plasma membrane] (Homo sapiens)
Phosphorylation of STAT1 by JAK kinases (Homo sapiens)
STAT1 bound to p-IFNGR1 [plasma membrane] (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:p-JAK1 [plasma membrane] (Homo sapiens)
p-Y457-IFNGR1 [plasma membrane] (Homo sapiens)
p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:p-JAK1 [plasma membrane] (Homo sapiens)
p-Y457-IFNGR1 [plasma membrane] (Homo sapiens)
Release of STAT1 dimer from active receptor unit (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:p-JAK1 [plasma membrane] (Homo sapiens)
p-Y457-IFNGR1 [plasma membrane] (Homo sapiens)
p-STAT1 dimer bound to p-IFNGR1 [plasma membrane] (Homo sapiens)
IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:pJAK1:IFNGR2:p-JAK2 [plasma membrane] (Homo sapiens)
p-IFNGR1:p-JAK1 [plasma membrane] (Homo sapiens)
p-Y457-IFNGR1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P15260 IFNGR1
Gene Names
IFNGR1
Chain
signal peptide:1-17, chain:18-489
Reference Genes
BioGPS Gene:3459 IFNGR1
COSMIC (genes):IFNGR1 IFNGR1
CTD Gene:3459 IFNGR1
dbSNP Gene:3459 IFNGR1
ENSEMBL:ENSG00000027697 IFNGR1
HGNC:5439 IFNGR1
KEGG:hsa:3459 IFNGR1
Monarch:3459 IFNGR1
NCBI Gene:3459 IFNGR1
OMIM:107470 IFNGR1
UCSC:P15260 IFNGR1
Reference Transcript
RefSeq:NM_000416.2 IFNGR1
Other Identifiers
1038_s_at
11729406_a_at
11748152_a_at
17024144
202727_PM_s_at
202727_s_at
211676_PM_s_at
211676_s_at
2976114
2976115
2976116
2976117
2976118
2976121
2976123
2976124
2976126
2976127
2976128
2976129
2976130
2976131
2976132
2976134
2976135
2976136
3459
8129861
A_23_P8281
GE57475
GO:0001774
GO:0002376
GO:0004896
GO:0004906
GO:0005515
GO:0005886
GO:0007165
GO:0009615
GO:0010628
GO:0016020
GO:0019221
GO:0019955
GO:0032760
GO:0038196
GO:0048143
GO:0060089
GO:0060333
GO:0098586
GO:1900222
GO:1902004
HMNXSV003026999
PH_hs_0010701
TC06002152.hg
U19247_rna1_s_at
g13562048_3p_s_at
g4557879_3p_s_at
Participates
as a component of
p-IFNGR1:p-JAK1 [plasma membrane] (Homo sapiens)
Other forms of this molecule
IFNGR1 [plasma membrane]
Inferred To
phospho-Ifngr1 [plasma membrane]
(Mus musculus)
phospho-Ifngr1 [plasma membrane]
(Rattus norvegicus)
phospho-IFNGR1 [plasma membrane]
(Bos taurus)
phospho-IFNGR1 [plasma membrane]
(Canis familiaris)
phospho-IFNGR1 [plasma membrane]
(Sus scrofa)
phospho-p-Y457-IFNGR1 [plasma membrane]
(Gallus gallus)
Ghost homologue of p-Y457-IFNGR1 [plasma membrane]
(Danio rerio)
Modified Residues
Name
O4'-phospho-L-tyrosine at 457
Coordinate
457
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_000407.1
Guide to Pharmacology - Targets
1725
ENSEMBL
ENSP00000356713
,
ENST00000367739
OpenTargets
ENSG00000027697
HPA
ENSG00000027697-IFNGR1
PRO
P15260
Pharos - Targets
P15260
GlyGen
P15260
Orphanet
IFNGR1
PDB
1JRH
,
1FYH
,
1FG9
,
6E3K
,
6E3L
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01579 IFNG
1
IFNG [extracellular region]
(R-HSA-629621)
0.779
5
UniProt:P42224 STAT1
8
STAT1 [cytosol]
(R-HSA-629622)
p-Y701-STAT1 [cytosol]
(R-HSA-3132766)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-6788624)
p-Y701-STAT1 [cytosol]
(R-HSA-8951202)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-8985905)
p-Y701,S727-STAT1 [cytosol]
(R-HSA-9850842)
p-STAT1 [cytosol]
(R-HSA-8950418)
p-STAT1 [nucleoplasm]
(R-HSA-8987140)
0.69
4
UniProt:Q9UI95 MAD2L2
1
MAD2L2 [nucleoplasm]
(R-HSA-59092)
0.527
2
UniProt:Q9UM47 NOTCH3
20
Ub-NICD3 [cytosol]
(R-HSA-9021546)
Ub-NEXT3 [plasma membrane]
(R-HSA-9021545)
p-Y-NICD3 [cytosol]
(R-HSA-9018581)
Glc,GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane]
(R-HSA-1911429)
Glc,Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane]
(R-HSA-1911419)
NOTCH3(1572-2321) [Golgi membrane]
(R-HSA-156995)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [Golgi membrane]
(R-HSA-1983672)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [extracellular region]
(R-HSA-1983675)
NOTCH3(1572-2321) [plasma membrane]
(R-HSA-157231)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [Golgi membrane]
(R-HSA-1472871)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane]
(R-HSA-1467307)
10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane]
(R-HSA-1467382)
Pre-NOTCH3 [endoplasmic reticulum membrane]
(R-HSA-157102)
NICD3 [nucleoplasm]
(R-HSA-157928)
NICD3 [cytosol]
(R-HSA-157647)
NEXT3 [plasma membrane]
(R-HSA-157203)
NOTCH3(1629-1661) [plasma membrane]
(R-HSA-157657)
NOTCH3(40-1628) [extracellular region]
(R-HSA-157639)
FRINGE-modified NOTCH3 Extracellular fragment (NECD3) [Golgi membrane]
(R-HSA-1911522)
FRINGE-modified NOTCH3 Extracellular Fragment (NECD3) [plasma membrane]
(R-HSA-1911517)
0.527
2
UniProt:Q9NPF0 CD320
2
CD320 [plasma membrane]
(R-HSA-2980909)
CD320 E88del [plasma membrane]
(R-HSA-3325560)
0.527
2
UniProt:P23458 JAK1
6
p-Y-JAK1 [cytosol]
(R-HSA-451921)
JAK1 [cytosol]
(R-HSA-451898)
p-Y1034-JAK1 [cytosol]
(R-HSA-1112543)
p-JAK1 [cytosol]
(R-HSA-8950711)
JAK1 [endosome]
(R-HSA-8983168)
p-Y1034,Y1035-JAK1 [cytosol]
(R-HSA-9005335)
0.527
2
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