Translocation of STAT1 dimer to nucleus

Stable Identifier
R-HSA-873917
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Released GAF complex translocates to the nucleus and binds to the gamma-activated sequence (GAS) element present in the promoters of IFNG-regulated genes and induces the transcription of IFNG-responsive genes.

Literature References
PubMed ID Title Journal Year
12915721 The ins and outs of STAT1 nuclear transport

McBride, KM, Reich, NC

Sci STKE 2003
10982844 Regulation of STAT1 nuclear export by Jak1

Mowen, K, David, M

Mol Cell Biol 2000
7510216 Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

Shuai, K, Horvath, CM, Huang, LH, Qureshi, SA, Cowburn, D, Darnell JE, Jr

Cell 1994
Participants
Participant Of
Orthologous Events
Authored
Reviewed