Transphosphorylation of JAK1

Stable Identifier
R-HSA-873918
Type
Reaction
Species
Homo sapiens
Compartment
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The initial phosphorylation of JAK1 and JAK2 is mediated by JAK2. Autophosphorylated JAK2 may transphopshorylate JAK1 bound to IFNGR1 chain. Tyrosine 1033 in the activation loop of the JAK1 kinase domain may be the target for transphosphorylation (phosphorylation site mentioned here is based on sequence similarity with all the other JAK kinases).

Literature References
PubMed ID Title Journal Year
8631301 Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state

Briscoe, J, Rogers, NC, Witthuhn, BA, Watling, D, Harpur, AG, Wilks, AF, Stark, GR, Ihle, JN, Kerr, IM

EMBO J 1996
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2 [plasma membrane]
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Activity
This event is regulated
Orthologous Events
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