Phosphorylation of STAT1 by JAK kinases

Stable Identifier
R-HSA-873922
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

STAT1 pair recruited to the receptor complex is phosphorylated near the C-terminus at residue Y701, probably by JAK2. This phosphorylation enables the STAT1 homodimer formation which is further phosphorylated on residue S727.

Literature References
PubMed ID Title Journal Year
7690989 A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma

Shuai, K, Stark, GR, Kerr, IM, Darnell JE, Jr

Science 1993
7657660 Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor

Quelle, FW, Thierfelder, W, Witthuhn, BA, Tang, B, Cohen, S, Ihle, JN

J Biol Chem 1995
8631301 Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state

Briscoe, J, Rogers, NC, Witthuhn, BA, Watling, D, Harpur, AG, Wilks, AF, Stark, GR, Ihle, JN, Kerr, IM

EMBO J 1996
12040185 A road map for those who don't know JAK-STAT

Aaronson, DS, Horvath, CM

Science 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of STAT1 bound to p-IFNGR1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed