There will be a maintenance on OICR IT systems starting Friday Dec 15 at 6PM EST until midnight Sunday Dec 17; Reactome will be affected by this downtime

Service under maintenance from Friday Dec 15 at 6PM EST until midnight Sunday Dec 17

Release of STAT1 dimer from active receptor unit

Stable Identifier
R-HSA-873927
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The phosphorylated STAT1 on IFNGR1 chains homodimerize through reciprocal SH2-phosphotyrosine interactions to form p-STAT1 homodimer called gamma-activated-factor (GAF). This phosphorylated STAT1 homodimer disassociates from the receptor complex and translocates to the nucleus.

Participants
Participant Of
Orthologous Events