Release of STAT1 dimer from active receptor unit

Stable Identifier
R-HSA-873927
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The phosphorylated STAT1 on IFNGR1 chains homodimerize through reciprocal SH2-phosphotyrosine interactions to form p-STAT1 homodimer called gamma-activated-factor (GAF). This phosphorylated STAT1 homodimer disassociates from the receptor complex and translocates to the nucleus.

Literature References
PubMed ID Title Journal Year
12915721 The ins and outs of STAT1 nuclear transport

McBride, KM, Reich, NC

Sci STKE 2003
18591661 Tyrosine phosphorylation regulates the partitioning of STAT1 between different dimer conformations

Wenta, N, Strauss, H, Meyer, S, Vinkemeier, U

Proc Natl Acad Sci U S A 2008
7510216 Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

Shuai, K, Horvath, CM, Huang, LH, Qureshi, SA, Cowburn, D, Darnell JE, Jr

Cell 1994
Participants
Participant Of
Orthologous Events
Authored
Reviewed