SOCS-1 and SOCS-3 binds to p-JAK2

Stable Identifier
R-HSA-877269
Type
Reaction
Species
Homo sapiens
Compartment
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SOCS-1 and SOCS-3 coprecipitates with JAK kinases upon IFNG stimulation and are able to inhibit the JAK-STAT pathway, although with different affinity and kinetics. SOCS1 and SOCS3 binds to phosphorylated JAK1/2 and prevent the tyrosine kinase activity of JAKs through their kinase inhibitory region (KIR), thereby inhibiting downstream IFNG signaling. SOCS1 may also prevent IFNG signaling by targeting the signaling machinery to ubiquitin-proteasomal degradation pathway.

Literature References
PubMed ID Title Journal Year
10064597 The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop

Yasukawa, H, Misawa, H, Sakamoto, H, Masuhara, M, Sasaki, A, Wakioka, T, Ohtsuka, S, Imaizumi, T, Matsuda, T, Ihle, JN, Yoshimura, A

EMBO J 1999
10421843 Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain

Sasaki, A, Yasukawa, H, Suzuki, A, Kamizono, S, Syoda, T, Kinjyo, I, Sasaki, M, Johnston, JA, Yoshimura, A

Genes Cells 1999
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