PIAS1 binds p-STAT1 dimer

Stable Identifier
R-HSA-877281
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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PIAS1 protein interacts directly with phoshorylated STAT1 dimers and inhibit the transcriptional activity of STAT1 by blocking the DNA-binding domain of STAT1. It has also been suggested that PIAS proteins might regulate transcription by promoting small ubiquitin-related modifier (SUMO1) conjugation of STAT1. The significance of STAT1 sumoylation in regulating STAT1 activity is controversial and needs to be clarified.

Literature References
PubMed ID Title Journal Year
10805787 Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction

Liao, J, Fu, Y, Shuai, K

Proc Natl Acad Sci U S A 2000
18031232 PIAS proteins as regulators of small ubiquitin-related modifier (SUMO) modifications and transcription

Palvimo, JJ

Biochem Soc Trans 2007
12855578 PIAS proteins promote SUMO-1 conjugation to STAT1

Ungureanu, D, Vanhatupa, S, Kotaja, N, Yang, J, Aittomaki, S, Jänne, OA, Palvimo, JJ, Silvennoinen, O

Blood 2003
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created